Clone:
KJ1-26
Type of antibody:
Primary antibodies, Functional-grade antibodies
Isotype:
mouse IgG2a, mouse IgG2aκ
Applications:
FA, FC
Alternative names:
TCRA, Tcralpha

Specifications for DO11.10 TCR Antibody, anti-mouse

Overview

The DO11.10 mouse model is a valuable tool for studies of T cell immigration, immunoregulation, development, activation, and function. The KJ1-26 monoclonal antibody reacts with the T cell receptor (TCR) expressed on lymphocytes of the DO11.10 transgenic mouse and the TCR of the BALB/c-derived DO11.10 and DO11.10.24 T cell hybridoma. The DO11.10 TCR is specific for the chicken ovalbumin (OVA) peptide (323-339) in the context of I-A[d] major histocompatibility (MHC) molecules. Transgenic DO11.10 T cells also recognize OVA peptide from jungle fowl and turkey in the presence of A20-1.11, the H-2
d
-bearing, antigen-presenting B cell lymphoma.

Alternative names

TCRA, Tcralpha

Detailed product information

Technical specifications

CloneKJ1-26
Clonalitymonoclonal
Isotypemouse IgG2aκ, mouse IgG2a
Isotype controlIsotype Control Antibody, mouse IgG2a
Hostmouse
Type of antibodyPrimary antibodies, Functional-grade antibodies
Speciesmouse
AntigenDO11.10 TCR
Alternative names of antigenTCRA, Tcralpha
Distribution of antigenT cells
Entrez Gene ID21473
RRIDAB_2661331, AB_2661332, AB_2661333, AB_2661334, AB_2661335, AB_10828907

References for DO11.10 TCR Antibody, anti-mouse

Publications

  1. Haskins, K. et al. (1983) The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody. J. Exp. Med. 157(4): 1149-1169
  2. Marrack, P. et al. (1983) The major histocompatibility complex-restricted antigen receptor on T cells. IV. An antiidiotypic antibody predicts both antigen and I-specificity. J. Exp. Med. 158(5): 1635-1646
  3. Murphy, K. M. et al. (1990)
    Induction by antigen of intrathymic apoptosis of CD4
    +
    CD8
    +
    TCR
    lo
    thymocytes
    in vivo
    .
    Science 250(4988): 1720-1723

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DO11.10 TCR Antibody, anti-mouse

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