Clone:
REA1105
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Delta4

Specifications for DLL4 Antibody, anti-mouse, REAfinity™

Overview

Clone REA1105 recognizes the mouse DLL4, which is one of the six identified Notch ligands in vertebrates. Being a canonical Notch ligand, extracellular domain of DLL4 contains N-terminal domain, delta/serrate/LAG-2 (DSL) domain, and tandemly arranged multiple EGF–like repeats. Binding of canonical ligands such as DLL4 induces cleavage and release of Notch intracellular domain (NICD), followed by its translocation in the nucleus where it interacts with transcription factors involved in induction of expression of Notch target genes. As a ligand for Notch1, DLL4 is the first Notch ligand to be expressed during mouse development. DLL4 plays an important role in developmental angiogenesis. In mice, lack of a single DLL4 allele leads to early embryonic lethality characterized by severe defects in arterial differentiation and vascular remodeling.
Additional information: Clone REA1105 displays negligible binding to Fc receptors.

Alternative names

Delta4

Detailed product information

Technical specifications

CloneREA1105
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenDLL4
Alternative names of antigenDelta4
Molecular mass of antigen [kDa]72
Distribution of antigenendothelial cells, heart
Entrez Gene ID54485
RRIDAB_2733857, AB_2733415, AB_2733416, AB_2732994, AB_2732995, AB_2734035, AB_2734036, AB_2733544, AB_2733545, AB_2733856

References for DLL4 Antibody, anti-mouse, REAfinity™

Publications

  1. Duarte, A. et al. (2004) Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev. 18: 2474 -2478
  2. Krebs, L. T. et al. (2004) Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev. 18: 2469 -2473
  3. D'Souza, B. et al. (2010) Canonical and non-canonical Notch ligands. Curr Top Dev Biol. 92: 73-129

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