Clone:
REA1065
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
hdelta2, Delta-like4, Delta-like protein 4

Specifications for DLL4 Antibody, anti-human, REAfinity™

Overview

Clone REA1065 recognizes the human delta-like4 (DLL4) antigen, which is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. Notch signaling controls cell fate decisions and is involved in multiple developmental processes. Notch ligands are categorized into two subfamilies: the Jagged and the Delta ligand family. In mammals, five ligands (DLL 1, 3, and 4, Jagged 1 and 2) have been identified. DLL4 is highly expressed within vascular endothelial cells, thymic epithelial cells, and dendritic cell subsets and plays an important role for vascular development and homeostasis and thymic as well as peripheral T cell differentiation.
Additional information: Clone REA1065 displays negligible binding to Fc receptors.

Alternative names

hdelta2, Delta-like4, Delta-like protein 4

Detailed product information

Technical specifications

CloneREA1065
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenDLL4
Alternative names of antigenhdelta2, Delta-like4, Delta-like protein 4
Molecular mass of antigen [kDa]72
Distribution of antigendendritic cells, epithelial cells, endothelial cells
Entrez Gene ID54567
RRIDAB_2733662, AB_2733854, AB_2733855, AB_2733413, AB_2733414, AB_2733956, AB_2733957, AB_2734096, AB_2734097, AB_2732992, AB_2732993, AB_2733258, AB_2733259, AB_2733151, AB_2733152, AB_2733049, AB_2733050, AB_2734033, AB_2734034, AB_2733542, AB_2733543, AB_2733661

References for DLL4 Antibody, anti-human, REAfinity™

Publications

  1. Noguera-Troise, I. et al. (2006) Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 444(7122): 1032-1037
  2. Ridgeway, J. et al. (2006) Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 444(7122): 1083-1087
  3. Koch, U. et al. (2008) Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J. Exp. Med. 205(11): 2515-2523
  4. Hozumi, K. et al. (2008) Delta-like 4 is indispensable in thymic environment specific for T cell development. J. Exp. Med. 205(11): 2507-2513
  5. Radtke, F. et al. (2010) Notch signaling in the immune system. Immunity 32: 14-27

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DLL4 Antibody, anti-human, REAfinity™

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