Clone:
MHD4-46
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC
Alternative names:
hdelta2

Specifications for DLL4 Antibody, anti-human

Overview

The human delta-like4 (DLL4) is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. Notch signaling controls cell fate decisions and is involved in multiple developmental processes. Notch ligands are categorized into two subfamilies: the Jagged and the Delta ligand family. In mammals, five ligands (DLL 1, 3, and 4, Jagged 1 and 2) have been identified. DLL4 is highly expressed within vascular endothelial cells, thymic epithelial cells, and dendritic cell subsets and plays an important role for vascular development and homeostasis and thymic as well as peripheral T cell differentiation.

Alternative names

hdelta2

Detailed product information

Technical specifications

CloneMHD4-46
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenDLL4
Alternative names of antigenhdelta2
Molecular mass of antigen [kDa]72
Entrez Gene ID54567
RRIDAB_2651564, AB_10831209, AB_2651565, AB_10827749, AB_2651566, AB_2651567, AB_2651568, AB_2651569, AB_10827584, AB_2651563

References for DLL4 Antibody, anti-human

Publications

  1. Radtke, F. et al. (2010) Notch signaling in the immune system. Immunity 32(1): 14-27
  2. Noguera-Troise, I. et al. (2006) Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 444(7122): 1032-1037
  3. Ridgeway, J. et al. (2006) Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 444(7122): 1083-1087
  4. Hozumi, K. et al. (2008) Delta-like 4 is indispensable in thymic environment specific for T cell development J. Exp. Med. 205(11): 2507-2513
  5. Koch, U. et al. (2008) Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J. Exp. Med. 205(311): 2515-2523

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DLL4 Antibody, anti-human

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