Clone:
REA1110
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Delta1, DL1, Delta, DELT

Specifications for DLL1 Antibody, anti-human, REAfinity™

Overview

Clone REA1110 recognizes the human delta-like protein 1 (DLL1), a type I transmembrane protein expressed by various organs, such as heart, pancreas, brain, muscle, and the hematopetic system; it is relevant for the differentiation of various cell types. In the immune system, DLL1 is required for differentiation of marginal zone B cells and can be expressed by various antigen-presenting cells (APC) contributing to APC-directed peripheral T cell differentiation.
Additional information: Clone REA1110 displays negligible binding to Fc receptors.

Alternative names

Delta1, DL1, Delta, DELT

Detailed product information

Technical specifications

CloneREA1110
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenDLL1
Alternative names of antigenDelta1, DL1, Delta, DELT
Molecular mass of antigen [kDa]76
Distribution of antigenantigen-presenting cells, other, brain, heart, muscle, pancreas
Entrez Gene ID28514
RRIDAB_2732990, AB_2732991, AB_2733256, AB_2733257, AB_2733149, AB_2733150, AB_2734031, AB_2734032, AB_2733852, AB_2733853, AB_2733411, AB_2733412

References for DLL1 Antibody, anti-human, REAfinity™

Publications

  1. Dontja, W. et al. (2006) Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B. Blood 107(6): 2446-2452
  2. Jung, J. et al. (2011) Regulation of Notch1 signaling by Delta-like ligand 1 intracellular domain through physical interaction. Mol. Cell 32(2): 161-165
  3. Andrawes, M. B. et al. (2013) Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. J. Biol. Chem. 288(35): 25477-25489

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