Clone:
REA1001
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, FC
Alternative names:
CLEC4N, Clec6a, Clecsf10, Nkcl

Specifications for Dectin-2 Antibody, anti-mouse, REAfinity™

Overview

Clone REA1001 recognizes the mouse dendritic cell–associated C-type lectin 2 (dectin-2) antigen. Dectin-2 is a type II membrane protein and contains a single carbohydrate recognition domain. Like other C-type lectins, mouse dectin-2 has conserved motifs for the Ca
2+
-dependent recognition of mannose. Dectin-2 is located in the natural killer gene complex of chromosome 6. Genomic analyses show that beside a full length dectin-2 transcript two truncated isoforms are produced by alternative splicing, encoding transmembrane proteins of 168–209 amino acids. The expression of dectin-2 on mouse monocytes and macrophages can be induced by zymosan and thioglycollate. Dectin-2 plays a physiological role in antigen presentation and antigen targeting via dectin-2 can induce a CD8
+
T cell response.
Additional information: Clone REA1001 displays negligible binding to Fc receptors.

Alternative names

CLEC4N, Clec6a, Clecsf10, Nkcl

Detailed product information

Technical specifications

CloneREA1001
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenDectin-2
Alternative names of antigenCLEC4N, Clec6a, Clecsf10, Nkcl
Molecular mass of antigen [kDa]24
Distribution of antigenmacrophages, monocytes
Entrez Gene ID56620
RRIDAB_2733702, AB_2733291

References for Dectin-2 Antibody, anti-mouse, REAfinity™

Publications

  1. Fernandes, M. J. et al. (1999) Characterization of a novel receptor that maps near the natural killer gene complex: demonstration of carbohydrate binding and expression in hematopoietic cells. Cancer Res. 59: 2709-2717
  2. Ariizumi, K. et al. (2000) Cloning of a second dendritic cell-associated C-type lectin (dectin-2) and its alternatively spliced isoforms. J. Biol. Chem. 275: 11957-11963
  3. Taylor, P. R. et al. (2005)
    Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited
    in vivo
    .
    Eur. J. Immunol. 35: 2163-2174
  4. Carter, R. W. et al. (2006)
    Induction of CD8
    +
    T cell responses through targeting of antigen to Dectin-2.
    Cell. Immunol. 239: 87-91

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