Clone:
REA329
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CLEC4A, CD367, CLECSF6, DDB27, HDCGC13P, LLIR

Specifications for DCIR Antibody, anti-human, REAfinity™

Overview

Clone REA329 recognizes the human dendritic cell immunoreceptor (DCIR) antigen, a single-pass type II membrane protein with a single carbohydrate recognition domain which is also known as C-type lectin domain family 4 member A (CLEC4A) or lectin-like immunoreceptor (LLIR). DCIR is expressed on dendritic cells (DCs), monocytes, macrophages, B lymphocytes, and granulocytes, but not detected on NK and T cells. DCIR is strongly expressed by DC derived from blood monocytes cultured with GM-CSF and IL-4. It is mostly expressed by monocyte-related rather than Langerhans cell related DC obtained from CD34
+
progenitor cells. Finally, DCIR expression is down-regulated by signals inducing DC maturation such as CD40 ligand, LPS, or TNF-α. Thus, DCIR is differentially expressed on DC depending on their origin and stage of maturation/activation.
Additional information: Clone REA329 displays negligible binding to Fc receptors.

Alternative names

CLEC4A, CD367, CLECSF6, DDB27, HDCGC13P, LLIR

Detailed product information

Technical specifications

CloneREA329
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenDCIR
Alternative names of antigenCLEC4A, CD367, CLECSF6, DDB27, HDCGC13P, LLIR
Molecular mass of antigen [kDa]28
Distribution of antigendendritic cells, monocytes, macrophages, B cells, lymphocytes, granulocytes
Entrez Gene ID50856
RRIDAB_2651506, AB_2651507, AB_2651508, AB_2651509, AB_2651510, AB_2651511, AB_2651512, AB_2651515, AB_2651516, AB_2651505

References for DCIR Antibody, anti-human, REAfinity™

Publications

  1. Bates, E. E. et al. (1999) APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif. J. Immunol. 163(4): 1973-1983
  2. Richard, M. et al. (2002) The expression pattern of the ITIM-bearing lectin CLECSF6 in neutrophils suggests a key role in the control of inflammation. J. Leukoc. Biol. 71(5): 871-880
  3. Bloen, K. et al. (2013) Ligand binding and signaling of dendritic cell immunoreceptor (DCIR) is modulated by the glycosylation of the carbohydrate recognition domain. PLoS One 8(6): e66266

Related products for
DCIR Antibody, anti-human, REAfinity™

2 products available