Clone:
REA900
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
KARAP, TYROBP

Specifications for DAP12 Antibody, anti-human, REAfinity™

Overview

Clone REA900 recognizes the human DAP12 antigen, a transmembrane signaling polypeptide which consists of an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. DAP12 interacts with several members of the CD300 molecule-like family, CLECSF5 and Siglec14. The association of DAP12 with triggering receptor expressed on myeloid cells (TREM-1) and myeloid DAP12-associating lectin (MDL-1) plays a role in monocytic activation and inflammatory response. DAP12 is found in several tissues, but also in peripheral blood leukocytes.
Additional information: Clone REA900 displays negligible binding to Fc receptors.

Alternative names

KARAP, TYROBP

Detailed product information

Technical specifications

CloneREA900
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenDAP12
Alternative names of antigenKARAP, TYROBP
Molecular mass of antigen [kDa]10
Distribution of antigenleukocytes, monocytes, other, brain, spleen
Entrez Gene ID7305
RRIDAB_2726906, AB_2726872, AB_2726907, AB_2726873

References for DAP12 Antibody, anti-human, REAfinity™

Publications

  1. Tomasello, E. et al. (2000) Association of signal-regulatory proteins beta with KARAP/DAP-12. Eur. J. Immunol. 30(8): 2147-2156
  2. Gingras, M. S. et al. (2002) TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development. Mol. Immunol. 38(11): 817-824

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