Clone:
REA914
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MICS, IF, IHC

Specifications for Cytokeratin HMW Antibody, anti-human, REAfinity™

Overview

Clone REA914 recognizes the human Cytokeratin HMW (High Molecular Weight), which includes the cytokeratins 1,5,10 and 14. Keratins are polypeptides with keratin-containing intermediate filaments, which play a critical role in mechanical stability and integrity of epithelial cells and tissues, have regulatory functions and are involved in intracellular signaling pathways. Clone REA914 detects squamous and ductal epithelium and other complex epithelia in normal tissues, e.g. basal cells in prostate, and myoepithelial cells in breast and corresponding tumors.
Additional information: Clone REA914 displays negligible binding to Fc receptors.

Detailed product information

Technical specifications

CloneREA914
Clonalitymonoclonal
Isotyperecombinant human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCytokeratin HMW
Distribution of antigenepithelial cells, tumor cells
RRIDAB_2857388, AB_2857389, AB_2857387

References for Cytokeratin HMW Antibody, anti-human, REAfinity™

Publications

  1. Moll, R. et al. (1982) The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell 31(1): 11-24
  2. Yang, D. et al. (1999) Beta-defensins: Linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286(5439): 525-528
  3. Yang, X. J. et al. (1999) Rare expression of high-molecular-weight cytokeratin in adenocarcinoma of the prostate gland: a study of 100 cases of metastatic and locally advanced prostate cancer. Am. J. Surg. Pathol. 23(2): 147-152

Seems like you are coming from USA!
Do you want to visit our website in your country?