Clone:
REAL685
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
KRT18, CK-18, Keratin-18, K18

Specifications for Cytokeratin 18 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL685 is an antibody fragment derived from the full Cytokeratin 18 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL685 specifically recognizes cytokeratin 18 (K18). Cytokeratins are located in the intracytoplasmic cytoskeleton of epithelial tissue. Cytokeratin 18 is frequently used in conjunction with keratin 8 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells and to enumerate circulating tumor cells in blood. Gene mutations of Keratin 18 lead in cryptogenic cirrhosis.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

KRT18, CK-18, Keratin-18, K18

Detailed product information

Technical specifications

CloneREAL685
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCytokeratin 18
Alternative names of antigenKRT18, CK-18, Keratin-18, K18
Distribution of antigenepithelial cells, breast cancer cells, other, colon, placenta, liver

References for Cytokeratin 18 Antibody, anti-human, REAdye_lease™

Publications

  1. Ku, N. O. et al. (2003) Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies. Proc. Natl. Acad. Sci. U.S.A. 100(10): 6063-6068
  2. Oshima, R. G. et al. (1986) Comparison of mouse and human keratin 18: a component of intermediate filaments expressed prior to implantation. Differentiation 33(1): 61-68
  3. Waseem, A. et al. (1990) Embryonic simple epithelial keratins 8 and 18: chromosomal location emphasizes difference from other keratin pairs. New Biol. 2(5): 464-478

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