Clone:
REA365
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
CMK, γ-interferon-induced monokine, MuMIG, Scyb9, crg-10, MIG

Specifications for CXCL9 (MIG) Antibody, anti-mouse, REAfinity™

Overview

Clone REA365 recognizes the mouse C-X-C motif chemokine ligand 9 (CXCL9) antigen, a small cytokine belonging to the CXC chemokine family that is also known as Monokine induced by interferon γ (MIG). CXCL9 is a T-cell chemoattractant, which is induced by IFN-γ during infection, injury or immunoinflammatory responses in macrophages, hepatocytes, and endothelial cells. It is best known for its role in leucocyte trafficking, principally acting on activated CD4
+
Th1 cells, CD8
+
T cells and NK cells. CXCL9 also has angiostatic properties. Overexpression of CXCL9 in tumors can lead to T-cell accumulation, vascular damage, and tumor regression. It elicits its chemotactic functions by interacting with the chemokine receptor CXCR3.
Additional information: Clone REA365 displays negligible binding to Fc receptors.

Alternative names

CMK, γ-interferon-induced monokine, MuMIG, Scyb9, crg-10, MIG

Detailed product information

Technical specifications

CloneREA365
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCXCL9 (MIG)
Alternative names of antigenCMK, γ-interferon-induced monokine, MuMIG, Scyb9, crg-10, MIG
Molecular mass of antigen [kDa]12
Distribution of antigenendothelial cells, T cells, macrophages
Entrez Gene ID17329
RRIDAB_2651481, AB_2651482, AB_2651483, AB_2651480

References for CXCL9 (MIG) Antibody, anti-mouse, REAfinity™

Publications

  1. Giegold, O. et al. (2013) CXCL9 causes heterologous desensitization of CXCL12-mediated memory T lymphocyte activation. J. Immunol. 190(7): 3696-3705
  2. Kastenmüller, W. et al. (2013)
    Peripheral prepositioning and local CXCL9 chemokine-mediated guidance orchestrate rapid memory CD8
    +
    T cell responses in the lymph node.
    Immunity 38(3): 502-513
  3. Farber, J. M. et al. (1990) A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines. Proc. Natl. Acad. Sci. U.S.A. 87(14): 5238-5242

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CXCL9 (MIG) Antibody, anti-mouse, REAfinity™

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