Clone:
REAL694
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
COX IV-1 (Cytochrome c oxidase subunit IV isoform 1), Cytochrome c oxidase subunit 4 isoform 1, Cytochrome c oxidase polypeptide IV, COX4, COX IV

Specifications for COX-4 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL694 is an antibody fragment derived from the full COX-4 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL694 recognizes the human COX-4 protein, one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. COX-4 can be used to identify the inner membrane of mitochondria in immunfluorescence studies. Mutations in the gene have been associated with COX deficiency and Fanconi anemia.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

COX IV-1 (Cytochrome c oxidase subunit IV isoform 1), Cytochrome c oxidase subunit 4 isoform 1, Cytochrome c oxidase polypeptide IV, COX4, COX IV

Detailed product information

Technical specifications

CloneREAL694
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
Cross-reactivityrat
AntigenCOX-4
Alternative names of antigenCOX IV-1 (Cytochrome c oxidase subunit IV isoform 1), Cytochrome c oxidase subunit 4 isoform 1, Cytochrome c oxidase polypeptide IV, COX4, COX IV

References for COX-4 Antibody, anti-human, REAdye_lease™

Publications

  1. Böttinger, L. et al. (2013) A complex of Cox4 and mitochondrial Hsp70 plays an important role in the assembly of the cytochrome c oxidase. Mol. Biol. Cell 24(17): 2609-2619
  2. Oliva, C. R. et al. (2015) Nuclear-encoded cytochrome c oxidase subunit 4 regulates BMI1 expression and determines proliferative capacity of high-grade gliomas. Oncotarget. 6(6): 4330-4344

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