Clone:
REA898
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CLDN4, CPER, CPE-R, CPETR1, WBSCR8

Specifications for Claudin-4 Antibody, anti-human, REAfinity™

Overview

Clone REA898 recognizes the human claudin-4 antigen, an integral membrane protein with four transmembrane segments, which is a component of the claudin family of epithelial tight junction proteins. Claudin is found in the intestinal mucosa epithelium and is highly expressed in pancreatic cancer. In association with EphA2 Claudin-4 is inveolved in the regulation of tight juctions and it plays a role in epithelial tissue development.
Additional information: Clone REA898 displays negligible binding to Fc receptors.

Alternative names

CLDN4, CPER, CPE-R, CPETR1, WBSCR8

Detailed product information

Technical specifications

CloneREA898
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenClaudin-4
Alternative names of antigenCLDN4, CPER, CPE-R, CPETR1, WBSCR8
Molecular mass of antigen [kDa]22
Distribution of antigentumor cells, pancreatic carcinoma cells
Entrez Gene ID1364
RRIDAB_2726851, AB_2726820, AB_2726852, AB_2726821, AB_2726849, AB_2726818, AB_2726819, AB_2726850

References for Claudin-4 Antibody, anti-human, REAfinity™

Publications

  1. Michl, P. et al. (2003) Claudin-4 expression decreases invasiveness and metastatic potential of pancreatic cancer. Cancer Res. 63(19): 6265-6271
  2. Tanaka, M. et al. (2005) EphA2 phosphorylates the cytoplasmic tail of Claudin-4 and mediates paracellular permeability. J. Biol. Chem. 280(51): 42375-42382

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