MACS GMP PepTivator® MAGE-A3

MACS GMP PepTivator

The MACS GMP PepTivator MAGE-A3 is a peptide pool that consists mainly of 15-mer peptides. It has been developed for efficient
in vitro
stimulation and subsequent isolation of MAGE-A3-specific CD4
and CD8
T cells.


MACS GMP Products are for research use and
ex vivo
cell culture processing only, and are not intended for human
in vivo
applications. For regulatory status in the USA, please contact your local representative.

Background information

The MAGE-A3 belongs to the melanoma antigen family and all members encode proteins with a high sequence similarity of up to 80% to each other. The expression of MAGE-A3 is restricted to the germ cells of testis but absent in somatic tissue except tumor cells.
In diagnostic application the protein is used for the identification of tumors like melanoma, non-small-lung cancer and hematologic malignancies. This makes MAGE-A3 to potent tumor-marker for immunotherapy.


The MACS GMP PepTivator MAGE-A3 is suitable for
in vitro
stimulation of CD4
and CD8
effector and memory T cells. The activated MAGE-A3-specific T cells secret IFN-gamma and can be enriched via the CliniMACS Cytokine Capture System (IFN-gamma).
Adoptive transfer of MAGE-A3-specific T cells or vaccination with MAGE-A3-pulsed dendritic cells may be an effective tool for the treatment of MAGE-A3-expressing malignancies.

Quality statement

MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.
  • Selected references

    1. Boon T. et al. (1996) Human tumor antigens recognized by T lymphocytes. J. Exp. Med. 183(3): 725-729
    2. Kobayashi H. et al. (2001) Tumor-reactive T helper lymphocytes recognize a promiscuous MAGE-A3 epitope presented by various major histocompatibility complex class II alleles Cancer Res. 61: 4773-4778
  • Certificates

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    to search for Certificates of Analysis (CoA) by lot number.
Product options: 1
stimulation of
EUR 2.495,00 

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