CD279 antibodies

CD279 antibodies

Clone: PD1.3.1.3
PD1.3.1.3 recognizes human CD279, also known as programmed death-1 (PD-1). It is a 55 kDa transmembran protein belonging to the CD28/CTLA-4 family. It is expressed on T cells, B cells, NK cells, and activated myeloid cells. CD279 is not expressed on naive T cells but induced after activation and expressed on late, differentiated T cells. The ligands PD-L1 (B7-H1; CD274) and PD-L2 (B7-DC; CD273) belong to the B7 immunglobulin superfamily. PD1 and its ligands mediate inhibitory signals that regulate the balance between T cell activation, tolerance, and immunopathology. Clone PD.1.3.1.3 has been used to block the binding of both ligands.

Applications

Reagent can be used for immunophenotyping by flow cytometry. Abnormal numbers of cells expressing this antigen or aberrant expression levels of the antigen can be expected in some disease states. It is important to understand the normal expression pattern for this antigen and its relationship to expression of other relevant antigens in order to perform appropriate analysis.
Expression of CD279 may be used as aid to diagnostic in the characterization of samples from individuals suspected with hematologic neoplasia.

Technical specifications

  • Antigen: CD279
  • Clone: PD1.3.1.3
  • Isotype: mouse IgG2bκ
  • Molecular mass of antigen [kDa]: 29
  • Distribution of antigen: B cells, monocytes, spleen, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Brochures and posters

  • Certificates of Analysis (CoA)

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Product options: 2

Product information

Size
Order no.
Price

CD279-PE

  • PD1.3.1.3
  • CE–IVD
for 50
tests
170-078-044
EUR 341,00 

CD279-APC

  • PD1.3.1.3
  • CE–IVD
for 50
tests
170-078-092
EUR 341,00