Clone:
REA387
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC, MC
Alternative names:
SLC3A2, SLC7A5, 4F2hc

Specifications for CD98 Antibody, anti-human, REAfinity™

Overview

Clone REA387 recognizes the human CD98 antigen, a single-pass type II membrane glycoprotein. CD98 is broadly expressed on non-hematopoietic cells and also on peripheral blood lymphocytes, monocytes, and granulocytes. The CD98 heterodimer consists of a 80–85 kDa heavy chain (CD98hc, also known as 4F2 antigen heavy chain or FRP-1) that is disulfide-linked with a multi-pass light chain of 40 kDa. The heavy chain binds to the cytoplasmic tails of integrin-β chains and mediates adhesive signals that control cell spreading, survival, and growth. The light chain functions in amino acid transport. Some of the light chains have broad specificity, but the large neutral amino acid transporters LAT-1 and LAT-2 have preference for importing certain essential amino acids, particularly leucine, isoleucine, and arginine (LAT-1), in exchange for glutamine. Through its nutrient function, CD98 can contribute to the survival and growth of many cell types. CD98hc functions in amplifying integrin signaling and in the transport of amino acids. Both of these functions can contribute to cell survival and proliferation.
Additional information: Clone REA387 displays negligible binding to Fc receptors.

Alternative names

SLC3A2, SLC7A5, 4F2hc

Detailed product information

Technical specifications

CloneREA387
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate
Cross-reactivity
olive baboon (
Papio anubis
)
,
chimpanzee (
Pan troglodytes
)
AntigenCD98
Alternative names of antigenSLC3A2, SLC7A5, 4F2hc
Molecular mass of antigen [kDa]123
Distribution of antigengranulocytes, monocytes, lymphocytes
Entrez Gene ID6520, 8140
RRIDAB_2751975, AB_2801870, AB_2877021, AB_2877022, AB_2659680, AB_2659681, AB_2659688, AB_2659689, AB_2659690, AB_2659691, AB_2752005

Reviews for CD98 Antibody, anti-human, REAfinity™

Good CD98 Staining On Human PBMCs

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CD98-PE-Vio770, human (130-105-710)

The aim of this study was to observe activation markers upon CD3/CD28 stimulation and HIV infection of purified human CD4+ T cells. I selected this product as Miltenyi offers high quality antibodies at good prices, and is the only company offering CD98 Ab conjugated to PE-Cy7-like dye.

References for CD98 Antibody, anti-human, REAfinity™

Publications

  1. Quackenbush, E. et al. (1987) Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth. Proc. Natl. Acad. Sci. U.S.A. 84(18): 6526-6530
  2. Cantor, J. M. et al. (2012) CD98 at the crossroads of adaptive immunity and cancer. J. Cell. Sci. 125(6): 1373-1382
  3. Kanai, Y. et al. (1998) Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J. Biol. Chem. 273(37): 23629-23632

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CD98 Antibody, anti-human, REAfinity™

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