Clone:
REA1242
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
ADGRE5, TM7LN1, EMR1

Specifications for CD97 Antibody, anti-human, REAfinity™

Overview

Clone REA1242 reacts with the human CD97 antigen, a member of the epidermal growth factor (EGF)-TM7 family of cell surface receptors. CD97 is expressed by various cell types of the hematopoietic system and also on smooth muscle cells. Highest constitutive expression is found on granulocytes and monocytes. Lymphocytes express CD97 at lower level (T and NK cells expressing higher levels than B cells) but on T cells CD97 is upregulated upon activation via CD3 and CD28 or PHA. CD97 is a ligand for CD55 (decay-accelerating factor, DAF) and has been shown to mediate cell adhesion and co-stimulation of T cell proliferation.
Additional information: Clone REA1242 displays negligible binding to Fc receptors.

Alternative names

ADGRE5, TM7LN1, EMR1

Detailed product information

Technical specifications

CloneREA1242
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD97
Alternative names of antigenADGRE5, TM7LN1, EMR1
Molecular mass of antigen [kDa]90
Distribution of antigengranulocytes, monocytes, B cells, T cells, NK cells, smooth muscle
Entrez Gene ID976
RRIDAB_2819726, AB_2819731, AB_2819727, AB_2819732, AB_2819728, AB_2819733, AB_2819729, AB_2819730

References for CD97 Antibody, anti-human, REAfinity™

Publications

  1. Hamann, J. et al. (1995) Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain. J. Immunol. 155(4): 1942-1950