Clone:
REA1186
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Killer cell lectin-like receptor subfamily D member 1 (KLRD1), KLRD1

Specifications for CD94 Antibody, anti-mouse, REAfinity™

Overview

Clone REA1186 recognizes the murine CD94 antigen, an approximately 70 kDa single-pass type II transmembrane protein, which belongs to C-type lectin superfamily. CD94 associates covalently with NKG2 family members and forms disulfide bonded heterodimers. CD94-NKG2 receptors bind HLA-E, the nonclassical MHC class Ib molecule. Depending on the associated NKG2 member, CD94-NKG2 heterodimer transmits either activating or inhibitory signal. For e.g via immunoreceptor tyrosine based-inhibitory motifs (ITIMs) containing NKG2A, CD94-NKG2A heterodimers inhibit NK cell cytotoxicity. Besides NK cells, expression of CD94-NKG2 heterodimers is also shown on NK-T cells and a small percentage of CD8
+
cells in most mouse strains. DBA/2J mice do not express CD94.
Additional information: Clone REA1186 displays negligible binding to Fc receptors.

Alternative names

Killer cell lectin-like receptor subfamily D member 1 (KLRD1), KLRD1

Detailed product information

Technical specifications

CloneREA1186
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD94
Alternative names of antigenKiller cell lectin-like receptor subfamily D member 1 (KLRD1), KLRD1
Molecular mass of antigen [kDa]21
Distribution of antigenNK cells
Entrez Gene ID11643
RRIDAB_2784312, AB_2784309, AB_2784315, AB_2784314, AB_2784317, AB_2784316, AB_2784319, AB_2784318, AB_2784311, AB_2784310, AB_2784313

References for CD94 Antibody, anti-mouse, REAfinity™

Publications

  1. Vance, R. E. et al. (1997) Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells. Eur. J. Immunol. 27(12): 3236-3241
  2. Ho, E. L. et al. (1998) Murine Nkg2d and CD94 are clustered within the natural killer complex and are expressed independently in natural killer cells. Proc. Natl. Acad. Sci. U.S.A. 95(11): 6320-6325

Related products for
CD94 Antibody, anti-mouse, REAfinity™

2 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?