Clone:
SN4 C3-3A2
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC, MICS, IF, IHC
Alternative names:
BTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, Tspan29

Specifications for CD9 Antibody, anti-human

Overview

Clone SN4 C3-3A2 recognizes the human CD9 antigen, a 24 kDa cell surface glycoprotein which is also known as tetraspanin-29 (Tspan-29). CD9 belongs to the tetraspanin family of integral proteins, which are characterised by the presence of four conserved transmembrane domains, a small and two large extracellular loops. Expression of CD9 is found on platelets, pre–B cells, fibroblasts, eosinophils, macrophages, basophils, epithelial cells, oocytes, and activated T cells. Further expression is reported on malignant cells and tumor cell lines where CD9 is involved in supressor functions, inhibition of cell invasion, and metastasis. CD9 associates with other tetraspanin members, cell adhesion molecules such as EpCAM, integrin subsets, transmembrane proteins (EWI-2 and EWI-F), choline receptors, and G-proteins. Through diverse interactions or via direct stimulation, CD9 influences various cellular functions including cell adhesion, aggregation, migration, clustering of MHC molecules in dendritic cells (DCs), and provides co-stimulatory signal during T cell activation.

Alternative names

BTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, Tspan29

Detailed product information

Technical specifications

CloneSN4 C3-3A2
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD9
Alternative names of antigenBTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, Tspan29
Molecular mass of antigen [kDa]25
Distribution of antigenfibroblasts, macrophages, platelets, T cells, eosinophils, basophils
Entrez Gene ID928
RRIDAB_2857632, AB_2659573, AB_2571528, AB_2659574, AB_2659575, AB_2659576, AB_2659577, AB_2659578, AB_2659579, AB_2659580, AB_2659581, AB_2857657

References for CD9 Antibody, anti-human

Publications

  1. Jones, E. L. et al. (2011) Tetraspanins in cellular immunity. Biochem. Soc. T. 39(2): 506-511
  2. Hemler, M. E. (2003) Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain. Annu. Rev. Cell Dev. Biol. 19: 397-342
  3. Wang, H. X. et al. (2011) The C-terminal tail of tetraspanin protein CD9 contributes to its function and molecular organization. Cell. Sci. 124: 2702-2710

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