Clone:
20/70
Type of antibody:
Primary antibodies
Isotype:
rat IgG2bκ
Applications:
FC, MICS, IF, IHC
Alternative names:
C5AR1, C5AR, C5R1, D7Msu1

Specifications for CD88 (C5AR) Antibody, anti-mouse

Overview

Clone 20/70 recognizes the mouse CD88 antigen, a 43 kDa G type protein–coupled receptor with seven membrane-spanning regions which is also known as C5a anaphylatoxin chemotactic receptor 1 (C5AR). CD88 is expressed on neutrophils and monocyte/macrophages, but it is also found on hepatocytes, epithelial cells, endothelial cells, tissue mast cells, and human fetal astrocytes. Constitutive CD88 expression was also detected on microglia and fibroblast-like cells but not by oligodendrocytes. CD88 is a receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. It stimulates chemotaxis, granule enzyme release, and superoxide anion production. Sulfation plays a critical role in the association of CD88 with C5a, but no significant role in the ability of CD88 to transduce a signal and mobilize calcium in response to a small peptide agonist.

Alternative names

C5AR1, C5AR, C5R1, D7Msu1

Detailed product information

Technical specifications

Clone20/70
Clonalitymonoclonal
Isotyperat IgG2bκ
Isotype controlIsotype Control Antibody, rat IgG2b
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD88 (C5AR)
Alternative names of antigenC5AR1, C5AR, C5R1, D7Msu1
Molecular mass of antigen [kDa]39
Distribution of antigenendothelial cells, epithelial cells, granulocytes, macrophages, monocytes, mast cells, astrocytes, fibroblasts, microglia, neutrophils, liver
Entrez Gene ID12273
RRIDAB_2659442, AB_2659443, AB_2659444, AB_2659445, AB_2659448, AB_2659449, AB_2659450, AB_2659451, AB_2659452, AB_2659453, AB_2659454, AB_2659455, AB_2659456, AB_2659457, AB_2752202

References for CD88 (C5AR) Antibody, anti-mouse

Publications

  1. Gerard, C. et al. (1992) Structural diversity in the extracellular faces of peptidergic G-protein-coupled receptors. Molecular cloning of the mouse C5a anaphylatoxin receptor. J. Immunol. 149(8): 2600-2606
  2. Sadik, C. D. et al. (2012) Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcγR signaling. Proc. Natl. Acad. Sci. U.S.A. 109(46): E3177-E3185
  3. Bosmann, M. et al. (2013) The interaction between C5a and both C5aR and C5L2 receptors is required for production of G-CSF during acute inflammation. Eur. J. Immunol. 43(7): 1907-1913

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