Clone:
REA1213
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
C5AR1, C5A, C5AR, C5R1

Specifications for CD88 (C5AR) Antibody, anti-human, REAfinity™

Overview

Clone REA1213 recognizes the human CD88 antigen, a 43 kDa G type protein–coupled receptor with seven membrane-spanning regions which is also known as C5a anaphylatoxin chemotactic receptor 1 (C5AR). CD88 expression is originally described on neutrophils and monocyte/macrophages, but it is also found on hepatocytes, epithelial cells, endothelial cells, tissue mast cells, and human fetal astrocytes. Constitutive CD88 expression was also detected on astrocytes, microglia, and fibroblast-like cells but not by oligodendrocytes. CD88 is a receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. It stimulates chemotaxis, granule enzyme release, and superoxide anion production. Sulfation plays a critical role in the association of CD88 with C5a, but no significant role in the ability of CD88 to transduce a signal and mobilize calcium in response to a small peptide agonist.
Additional information: Clone REA1213 displays negligible binding to Fc receptors.

Alternative names

C5AR1, C5A, C5AR, C5R1

Detailed product information

Technical specifications

CloneREA1213
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
Cross-reactivitybovine, ferret, rabbit
AntigenCD88 (C5AR)
Alternative names of antigenC5AR1, C5A, C5AR, C5R1
Molecular mass of antigen [kDa]39
Distribution of antigenhepatocytes, astrocytes, endothelial cells, epithelial cells, granulocytes, mast cells, monocytes, macrophages, microglia, other
Entrez Gene ID728
RRIDAB_2811499, AB_2811502, AB_2811500, AB_2811501

References for CD88 (C5AR) Antibody, anti-human, REAfinity™

Publications

  1. Gerard, N. P. et al. (1991) The chemotactic receptor for human C5a anaphylatoxin. Nature 349(6310): 614-617
  2. Farzan, M. et al. (2001) Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor. J. Exp. Med. 193(9): 1059-1066
  3. Buck, E. et al. (2005) Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor. Proc. Natl. Acad. Sci. U.S.A. 102: 2719-2724

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