Clone:
24F
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC
Alternative names:
B7-2, B70

Specifications for CD86 Antibody, anti-rat

Overview

Clone 24F recognizes the rat antigen CD86, also known as B7-2, which is a member of the B7 family of costimulatory molecules. In addition to CD80 (B7-1) , CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). It is expressed by germinal center B cells and weakly expressed on antigen presenting cells, such as macrophages and dendritic cells. Its expression is upregulated on B cells through a variety of surface stimuli including LPS. CD86 plays a critical role in the early events of T cell activation and costimulation of naive T cells as well as autoantibody and Tʜ2-mediated Ig production.

Alternative names

B7-2, B70

Detailed product information

Technical specifications

Clone24F
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Speciesrat
AntigenCD86
Alternative names of antigenB7-2, B70
Molecular mass of antigen [kDa]32
Distribution of antigenB cells, dendritic cells, macrophages, monocytes
Entrez Gene ID56822
RRIDAB_2857808, AB_2659398, AB_2659399, AB_2659402, AB_2659403, AB_2659406, AB_2659407, AB_2659408, AB_2659409, AB_2819700

References for CD86 Antibody, anti-rat

Publications

  1. Bluestone, J. A. et al. (1995) New perspectives of CD28-B7-mediated T cell costimulation. Immunity 2(6): 555-559
  2. Maeda, K. et al. (1997) Characterization of rat CD80 and CD86 by molecular cloning and mAb. Int. Immunol. 9(7): 993-1000
  3. Damoiseaux, J. G. et al. (1998) Costimulatory molecules CD80 and CD86 in the rat; tissue distribution and expression by antigen-presenting cells. J. Leukoc. Biol. 64(6): 803-809

Related products for
CD86 Antibody, anti-rat

2 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?