Clone:
PO3.3
Type of antibody:
Primary antibodies
Isotype:
rat IgG2bκ
Applications:
FC
Alternative names:
B7-2, B70, CLS1, Cd28l2, ETC-1, Ly-58, MB7-2, TS/A-2

Specifications for CD86 Antibody, anti-mouse

Overview

Antibody clone PO3.3 detects the CD86 antigen, also known as B7-2, an 80 kDa molecule and a member of the immunoglobulin superfamily. Together with CD80 (B7-1) it belongs to the B7 family of costimulatory molecules. CD86 is expressed on activated antigen-presenting cells, including B cells, dendritic cells, and monocytes/macrophages. The interaction of CD86 with its ligands CD28 and CD152 (CTLA- 4) plays a critical role in induction and regulation of immune responses, e.g., cross-talk between T and B cells, T cell costimulation, or immunoglobulin class-switching. Binding of CD86 to CD28 on T cells results in transduction of costimulatory signals for activation or proliferation of T cells, or cytokine production. In contrast, binding of CD86 to CTLA-4 regulates T cell activation and diminishes the immune response.

Alternative names

B7-2, B70, CLS1, Cd28l2, ETC-1, Ly-58, MB7-2, TS/A-2

Detailed product information

Technical specifications

ClonePO3.3
Clonalitymonoclonal
Isotyperat IgG2bκ
Isotype controlIsotype Control Antibody, rat IgG2b
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD86
Alternative names of antigenB7-2, B70, CLS1, Cd28l2, ETC-1, Ly-58, MB7-2, TS/A-2
Molecular mass of antigen [kDa]32
Distribution of antigenB cells, dendritic cells, endothelial cells, Langerhans cells, monocytes, T cells
Entrez Gene ID12524
RRIDAB_2811485, AB_2811413, AB_2660747, AB_2660749, AB_2660750, AB_2660753, AB_2660754, AB_2660755

References for CD86 Antibody, anti-mouse

Publications

  1. Kin, N. W. et al. (2006) CD86 stimulation on a B cell activates the phosphatidylinositol 3-kinase/Akt and phospholipase C gamma 2/protein kinase C alpha beta signaling pathways. J. Immunol. 176(11): 6727-6735
  2. Nakajima, A. et al. (1997) Requirement of CD28-CD86 co-stimulation in the interaction between antigen-primed T helper type 2 and B cells. Int. Immunol. 9(5): 637-644
  3. Zhu, X. Y. et al. (2005)
    Blockade of CD86 signaling facilitates a Tʜ2 bias at the maternal-fetal interface and expands peripheral CD4
    +
    CD25
    +
    regulatory T cells to rescue abortion-prone fetuses.
    Biol. Reprod. 72(2): 338-345

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