Clone:
HB15
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC
Alternative names:
BL11, HB15

Specifications for CD83 Antibody, anti-human

Overview

The CD83 antibody reacts with a 45 kDa glycoprotein member of the immunoglobulin superfamily of receptors, also known as HB15. In humans, CD83 is expressed on the surface of activated dendritic cells (DCs) and can therefore be used as a marker for the phenotypical characterization of DC maturation. CD83 plays a role in antigen presentation and lymphocyte activation.

Alternative names

BL11, HB15

Detailed product information

Technical specifications

CloneHB15
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman, non-human primate, other
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
,
cynomolgus monkey (
Macaca fascicularis
)
,
chimpanzee (
Pan troglodytes
)
, baboon, horse
AntigenCD83
Alternative names of antigenBL11, HB15
Molecular mass of antigen [kDa]21
Distribution of antigenB cells, dendritic cells, Langerhans cells, T cells, brain, spleen
Entrez Gene ID9308
RRIDAB_2660944, AB_10828800, AB_10830556, AB_10828809

References for CD83 Antibody, anti-human

Publications

  1. Zhou, L.-J. et al. (1992) A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of J. Immunol. 149: 735-742
  2. Zhou, L.-J. and Tedder, T. F. (1995) Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. J. Immunol. 154: 3821-3835
  3. Sallusto, F. and Lanzavecchia, A. (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 179: 1109-1118
  4. Cao, W. et al. (2005) CD83 is preformed inside monocytes, macrophages and dendritic cells, but it is only stably expressed on activated dendritic cells. Biochem. J. 385: 85-93
  5. Lechmann, M. et al. (2002) CD83 on dendritic cells: more than just a marker for maturation. Trends Immunol. 23: 273-275

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CD83 Antibody, anti-human

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