Clone:
REA1117
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
Ig-beta, B29, Igb

Specifications for CD79b Antibody, anti-mouse, REAfinity™

Overview

Clone REA1117 recognizes the mouse CD79b antigen, a 35–40kD single-pass type I membrane protein also known as B cell antigen receptor complex-associated protein beta chain (Igβ chain). The heterodimeric CD79 molecule is composed of an α chain (CD79a) and a β chain (CD79b) and is associated with surface immunoglobulins to form the B cell receptor. The CD79a/CD79b heterodimer facilitates the differentiation of pre–B cells from pro–B cells, surface expression of surface Ig, signal transduction following antigen recognition, and endocytosis of recognized antigens. Crosslinking of CD79b
in vitro
by monoclonal antibodies activates pre–B cells but blocks terminal differentiation of all plasma cell isotypes. It was shown that a combination of CD79a and CD79b monoclonal antibodies can effectively deplete B cells from peripheral blood, spleen, bone marrow, and lymph nodes in mice.
Additional information: Clone REA1117 displays negligible binding to Fc receptors.

Alternative names

Ig-beta, B29, Igb

Detailed product information

Technical specifications

CloneREA1117
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD79b
Alternative names of antigenIg-beta, B29, Igb
Molecular mass of antigen [kDa]23
Distribution of antigenB cells
Entrez Gene ID15985
RRIDAB_2751702, AB_2751682, AB_2751703, AB_2751683, AB_2751704, AB_2751705

References for CD79b Antibody, anti-mouse, REAfinity™

Publications

  1. Lin, J. and Justement, L. B. (1992) The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinases. J. Immunol. 149: 1548-1555
  2. O'Neill, S. K. et al. (2011) Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy. Immunity 35(5): 746-756
  3. Li, Y. et al. (2008) B cell depletion with anti-CD79 mAbs ameliorates autoimmune disease in MRL/lpr mice. J. Immunol. 181(5): 2961-2972

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