Clone:
5-329
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC, MICS, IF, IHC
Alternative names:
DHLAG, HLADG, II, Ia-GAMMA

Specifications for CD74 Antibody, anti-human

Overview

Clone 5-329 recognizes CD74, a non-polymorphic type II integral membrane protein. CD74 is also known as MHC class II–associated invariant chain and exists in multiple isoforms in human ranging from 33 to 43 kDa in size. Initially known for its role as the MHC II chaperone, CD74 primary function is suggested to regulate the MHC class II molecules folding and intracellular sorting. Recent studies however suggest further roles of CD74. It interacts with cytokine-like molecule called macrophage migration- inhibitory factor (MIF) and induce ERK1 and ERK2 signaling in a CD44 dependent manner. CD74 is also shown to form complexes with CXCR2 and CXCR4. A direct role of CD74 in the maturation of follicular B cells and accumulation of marginal zone B cells has also been suggested. CD74 was further shown to be one of the host molecules utilized by
H. pylori
to successfully attach to the gastric epithelial cells. Expression of CD74 is found on B cells, dendritic cells, epithelial cells, subsets of activated T cells, and low level expression is found on monocytes and macrophages.

Alternative names

DHLAG, HLADG, II, Ia-GAMMA

Detailed product information

Technical specifications

Clone5-329
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD74
Alternative names of antigenDHLAG, HLADG, II, Ia-GAMMA
Molecular mass of antigen [kDa]33
Distribution of antigenB cells, epithelial cells, dendritic cells
Entrez Gene ID972
RRIDAB_2659187, AB_2659188, AB_2659189, AB_2659190, AB_2659191, AB_2659192, AB_2659193, AB_2659194, AB_2659195, AB_2659196, AB_2659197, AB_2659198, AB_2659199, AB_2659186

References for CD74 Antibody, anti-human

Publications

  1. Leng, L. et al. (2003) MIF signal transduction initiated by binding to CD74. J. Exp. Med. 197: 1467-1476
  2. Beswick, E. J. and Reyes, V. E. (2009) CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract. World J Gastroenterol. 15(23): 2855-2861

Related products for
CD74 Antibody, anti-human

3 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?