Clone:
REA1244
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
GP40, Leu-9, TP41, Tp40

Specifications for CD7 Antibody, anti-human, REAfinity™

Overview

Clone REA1244 recognizes the human CD7 antigen, a single-pass type I membrane protein, also known as leu-9 or GP40. CD7 appears early in T cell ontogeny and is expressed by most T cells in the periphery. It is also found on NK cells, hematopoietic progenitors, monocytes, acute lymphocytic leukemia, and some acute myeloid leukemia cells. Although the ligand is yet not identified, CD7 has been recognized as a costimulatory molecule. CD7 activates phosphatidylinositol 3-kinase which is involved in CD7-mediated regulation of integrin adhesiveness. Furthermore, it has been reported that the β-galactoside-binding lectin galectin-1 binds CD7, leading to induction of apoptosis of thymocytes and T cells, with implications for certain autoimmune diseases and T cell lymphomas.
Additional Information: Clone REA1244 displays negligible binding to Fc receptors.

Alternative names

GP40, Leu-9, TP41, Tp40

Detailed product information

Technical specifications

CloneREA1244
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD7
Alternative names of antigenGP40, Leu-9, TP41, Tp40
Molecular mass of antigen [kDa]23
Distribution of antigenNK cells, T cells, stem cells, other
Entrez Gene ID924
RRIDAB_2819708, AB_2819718, AB_2819709, AB_2819719, AB_2819710, AB_2819720, AB_2819711, AB_2819721, AB_2819712, AB_2819722, AB_2819713, AB_2819723, AB_2819714, AB_2819724, AB_2819715, AB_2819725, AB_2819716, AB_2819717

References for CD7 Antibody, anti-human, REAfinity™

Publications

  1. Aruffo, A. et al. (1987) Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system. EMBO J. 6(11): 3313-3316
  2. Gallacher, L. et al. (2000)
    Isolation and characterization of human CD34
    Lin
    and CD34
    +
    Lin
    hematopoietic stem cells using cell surface markers AC133 and CD7.
    Blood 95(ARVO Annual Meeting Abstract): 2813-2820
  3. Kobayashi, S. et al. (2013) The CD3 versus CD7 plot in multicolor flow cytometry reflects progression of disease stage in patients infected with HTLV-I. PLoS One 8(1): e53728

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