Clone:
REAL1310
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
CEACAM6, NCA-90, NCA, CEAL

Specifications for CD66c Antibody, anti-human, REAdye_lease™

Overview

Clone REAL1310 is an antibody fragment derived from the full CD66c (CEACAM6) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1310 recognizes the human CD66c (CEACAM6) antigen, a glycosylphosphatidylinositol (GPI) linked protein which is also known as Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6). Within the hematopoietic system, CD66c expression is limited to granulocytes and its precursors, where it serves homotypic and heterotypic adhesion, Ca2+ mediated signaling and is markedly upregulated from intracellular stores after activation. It is also found in epithelia of various organs. CD66c overexpression is found in a wide variety of epithelial cancer types such as lung, breast, colorectal, and hepatocellular carcinomas.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

CEACAM6, NCA-90, NCA, CEAL

Detailed product information

Technical specifications

CloneREAL1310
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCD66c
Alternative names of antigenCEACAM6, NCA-90, NCA, CEAL
Distribution of antigengranulocytes, epithelial cells, tumor cells, cancer stem cells

Resources for CD66c Antibody, anti-human, REAdye_lease™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD66c Antibody, anti-human, REAdye_lease™

Publications

  1. Neumaier, M. et al. (1988) Characterization of a cDNA clone for the nonspecific cross-reacting antigen (NCA) and a comparison of NCA and carcinoembryonic antigen. J. Biol. Chem. 263(7): 3202-3207
  2. Guillaume, N. et al. (2011) CD66c expression in B-cell acute lymphoblastic leukemia: strength and weakness. Int J Lab Hematol 33(1): 92-96
  3. Gemei, M. et al. (2013) CD66c is a novel marker for colorectal cancer stem cell isolation, and its silencing halts tumor growth in vivo. Cancer 119(4): 729-738
  4. Kiyokawa, N. et al. (2014) Significance of CD66c expression in childhood acute lymphoblastic leukemia. Leuk. Res. 38(1): 42-48

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