Clone:
REA389
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
SELP, CD62, GMP-140, GRMP, LECAM3, PADGEM, PSEL, P-selectin

Specifications for CD62P Antibody, anti-human, REAfinity™

Overview

Clone REA389 recognizes the human CD62P antigen, a 140 kDa single-pass type I membrane protein also known as P-selectin or platelet activation dependent granule-external membrane protein (PADGEM). CD62P is expressed by vascular endothelial cells and platelets. The protein is stored preformed in the Weibel-Palade bodies of endothelial cells and in the α-granules of platelets. Upon stimulation of these cells with a variety of agonists such as thrombin or histamine, CD62P is rapidly translocated to the cell surface, where it mediates leukocyte-platelet and leukocyte-vascular endothelial cell adhesion. The interaction of CD62P with mature leukocytes is in part responsible for mediating leukocyte rolling on vascular cells – an early event in leukocyte recruitment at sites of inflammation. In addition to its role as a receptor for mature neutrophils and monocytes, CD62P also functions as a cell adhesion molecule for leukocyte precursor cells in the bone marrow, including both lineage-restricted clonogenic progenitors and hierarchically more primitive progenitor cells.
Additional information: Clone REA389 displays negligible binding to Fc receptors.

Alternative names

SELP, CD62, GMP-140, GRMP, LECAM3, PADGEM, PSEL, P-selectin

Detailed product information

Technical specifications

CloneREA389
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate
Cross-reactivity
chimpanzee (
Pan troglodytes
)
AntigenCD62P
Alternative names of antigenSELP, CD62, GMP-140, GRMP, LECAM3, PADGEM, PSEL, P-selectin
Molecular mass of antigen [kDa]86.2
Distribution of antigenendothelial cells, platelets
Entrez Gene ID6403
RRIDAB_2733831, AB_2733393, AB_2733394, AB_2784266, AB_2784265, AB_2658890, AB_2658891, AB_2733830

References for CD62P Antibody, anti-human, REAfinity™

Publications

  1. Zannettino, A. C. et al. (1995) Primitive human hematopoietic progenitors adhere to P-selectin (CD62P). Blood 3466(3477): 85-12
  2. Johnston, G. I. et al. (1989) Cloning of GMP-140, a granule membrane protein of platelets and endothelium: sequence similarity to proteins involved in cell adhesion and inflammation. Cell 56(6): 1033-1044
  3. Wickenhauser, C. et al. (2000) Selectins (CD62L, CD62P) and megakaryocytic glycoproteins (CD41a, CD42b) mediate megakaryocyte-fibroblast interactions in human bone marrow. Leuk. Res. 24(12): 1013-1021

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