Clone:
REA369
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
SELE, E-selectin, ELAM-1, Elam, LECAM2

Specifications for CD62E Antibody, anti-mouse, REAfinity™

Overview

Clone REA369 recognizes the mouse CD62E antigen, a single-pass type I membrane glycoprotein also known as E-selectin. CD62E is expressed on endothelial cells and plays a critical role in the recruitment of the appropriate blood cell into specific local sites. It mediates the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with P-selectin glycoprotein ligand 1, which promotes slow rolling and adhesion. CD62E is transcriptionally induced in response to inflammatory cytokines, such as IL-1β and TNFα. It has an important role during hematopoietic stem/progenitor cell trafficking to the bone marrow, and for the maintenance of their quiescent phenotype
in vivo
. Because selectins are also constitutively expressed in the endothelium of certain tissues such as bone marrow even in the absence of inflammatory stimulation, there has been a growing appreciation that these receptors may be important for tissue homeostasis. Elevated cellular levels of CD62E have been documented in various diseases associated with a pro-inflammatory condition, including diabetes, atherosclerosis, rheumatoid arthritis, and cancer. Conversely, therapeutic strategies, which reduce vascular injury, result in significant down-regulation of CD62E gene expression.
Additional information: Clone REA369 displays negligible binding to Fc receptors.

Alternative names

SELE, E-selectin, ELAM-1, Elam, LECAM2

Detailed product information

Technical specifications

CloneREA369
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD62E
Alternative names of antigenSELE, E-selectin, ELAM-1, Elam, LECAM2
Molecular mass of antigen [kDa]65
Distribution of antigenendothelial cells, bone marrow
Entrez Gene ID20339
RRIDAB_2876943, AB_2658842, AB_2658843, AB_2751781

References for CD62E Antibody, anti-mouse, REAfinity™

Publications

  1. Katayama, Y. et al. (2013) Selective E-selectin ligands. Blood 122(24): 3858-3860
  2. Weller, A. et al. (1992) Cloning of the mouse endothelial selectins. Expression of both E- and P-selectin is inducible by tumor necrosis factor alpha. J. Biol. Chem. 267(21): 15176-15183
  3. Laviola, L. et al. (2013) TNFα signals via p66(Shc) to induce E-selectin, promote leukocyte transmigration and enhance permeability in human endothelial cells. PLoS One 8(12): e81930

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