Clone:
REA1192
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Alternative names:
ITGB3, GP3A, INGRB3, GPIIIa, Integrin beta-3, Integrin β3

Specifications for CD61 Antibody, anti-mouse/rat, REAfinity™

Overview

Clone REA1192 recognizes a 110 kDa integrin β chain known as CD61 or integrin β3. Owing to multiple α/β subunit combinations, integrins form an array of heterodimeric receptors, each recognising a multitude of ligands. CD61, in association with either αv (CD51) or αIIb (CD41) integrin, binds to fibrinogen, fibronectin, von Willebrand factor, prothrombin, disintegrins, and thrombospondin. Due to binding to various extracellular matrix proteins and cellular receptors, integrins play a significant role in cell adhesion and cell movement. Furthermore, a pro-apoptotic function of CD61 has been suggested using a hepatocellular carcinoma (HCC) cell line and patient tissues. Expression of CD61 is found on platelets, B cell subsets, myeloid cells, mast cells, osteoclasts, endothelium, megakaryocytes, and smooth muscle cells.
Additional information: Clone REA1192 displays negligible binding to Fc receptors.

Alternative names

ITGB3, GP3A, INGRB3, GPIIIa, Integrin beta-3, Integrin β3

Detailed product information

Technical specifications

CloneREA1192
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse, rat
AntigenCD61
Alternative names of antigenITGB3, GP3A, INGRB3, GPIIIa, Integrin beta-3, Integrin β3
Molecular mass of antigen [kDa]84
Distribution of antigenB cell subsets, smooth muscle
Entrez Gene ID16416
RRIDAB_2801837, AB_2801838, AB_2801839, AB_2801840, AB_2801841, AB_2801836

References for CD61 Antibody, anti-mouse/rat, REAfinity™

Publications

  1. Plow, E. F. et al. (2000) Ligand binding to integrins. J. Biol. Chem. 275: 21785-21788

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