Type of antibody:
Releasable antibodies, Primary antibodies, Recombinant antibodies
Alternative names:
ICAM-1, Ly-47, MALA-2

Specifications for CD54 (ICAM-1) Antibody, anti-mouse,


Clone REAL289 is an antibody fragment derived from the full CD54 (ICAM-1) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REAL289 recognizes the murine CD54 antigen, a type I transmembrane glycoprotein also known as intercellular adhesion molecule 1 (ICAM-1). CD54 is continuously present in low concentrations in the membranes of monocytes/macrophages, lymphocytes, activated endothelial cells, granulocytes, and dendritic cells. Its expression is regulated by inflammatory cytokines and can be induced by interleukin 1 (IL-1) and tumor necrosis factor. CD54 is a ligand for LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). When activated, leukocytes bind to endothelial cells via CD54/LFA-1 and then transmigrate into tissues.
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative names

ICAM-1, Ly-47, MALA-2

Detailed product information

Technical specifications

Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable antibodies, Primary antibodies, Recombinant antibodies
AntigenCD54 (ICAM-1)
Alternative names of antigenICAM-1, Ly-47, MALA-2
Distribution of antigenmonocytes, macrophages, lymphocytes, endothelial cells, granulocytes, dendritic cells
RRIDAB_2784253, AB_2751300

References for CD54 (ICAM-1) Antibody, anti-mouse,


  1. Siu, G. et al. (1989) Isolation of the murine intercellular adhesion molecule 1 (ICAM-1) gene. ICAM-1 enhances antigen-specific T cell activation. J. Immunol. 143(11): 3813-3820
  2. Fine, J. S. et al. (1991) The role of LFA-1/ICAM-1 interactions during murine T lymphocyte development. J. Immunol. 147(9): 2852-2859
  3. Driessens, M. H. et al. (1996) Inhibition and stimulation of LFA-1 and Mac-1 functions by antibodies against murine CD18. Evidence that the LFA-1 binding sites for ICAM-1, -2, and -3 are distinct. J. Leukoc. Biol. 60(6): 758-765

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