Clone:
REA512
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Ox-44, TSPAN25

Specifications for CD53 Antibody, anti-rat, REAfinity™

Overview

Clone REA512 recognizes the rat CD53 antigen, also known as Ox-44, a 43 kDa glycoprotein and a member of the tetraspanin family, which has four transmembrane domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth, and motility. CD53 is expressed on almost all hematopoietic cells such as B cells, monocytes, macrophages, neutrophils, und T cells, but not on erythrocytes and platelets.
Additional information: Clone REA512 displays negligible binding to Fc receptors.

Alternative names

Ox-44, TSPAN25

Detailed product information

Technical specifications

CloneREA512
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesrat
AntigenCD53
Alternative names of antigenOx-44, TSPAN25
Molecular mass of antigen [kDa]24
Distribution of antigenB cells, macrophages, monocytes, T cells, neutrophils
Entrez Gene ID24251
RRIDAB_2658669, AB_2658670, AB_2658671, AB_2658672, AB_2658673, AB_2658674, AB_2658675, AB_2658676, AB_2658677, AB_2658678, AB_2658679, AB_2658668

References for CD53 Antibody, anti-rat, REAfinity™

Publications

  1. Tomlinson, M. G. (1993) Epitope mapping of anti-rat CD53 monoclonal antibodies. Implications for the membrane orientation of the Transmembrane 4 Superfamily. Eur. J. Immunol. 23(1): 136-140
  2. Lazo, P. A. et al. (1997) Ligation of CD53/OX44, a tetraspan antigen, induces homotypic adhesion mediated by specific cell-cell interactions. Cell. Immunol. 178(2): 132-140
  3. Bellacosa, A. (1991) The rat leukocyte antigen MRC OX-44 is a member of a new family of cell surface proteins which appear to be involved in growth regulation. Mol. Cell. Biol. 11(5): 2864-2872

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