Clone:
REA518
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
ITGA6, CD49fB, VLA-6, VLA-6α

Specifications for CD49f Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA518 recognizes the human and mouse CD49f antigen, a 120 kDa single-pass type I membrane protein, which is also known as integrin alpha-6 (ITGA6). Integrins are integral cell-surface proteins composed of an α chain and a β chain and are involved in cell adhesion as well as cell-surface mediated signaling. CD49f associates with integrin β1 chain (CD29) to form VLA-6 and with integrin β4 chain (CD104) to form the α6 β4 complex, which plays a critical structural role in the hemidesmosome and constitutes a receptor for laminin in epithelial cells. CD49f is furthermore expressed on T cells, monocytes, platelets, endothelial cells, trophoblasts of placenta, and spermatogonial stem cells.
Additional information: Clone REA518 displays negligible binding to Fc receptors.

Alternative names

ITGA6, CD49fB, VLA-6, VLA-6α

Detailed product information

Technical specifications

CloneREA518
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, non-human primate, other
Cross-reactivityporcine, dog,
rhesus monkey (
Macaca mulatta
)
,
cynomolgus monkey (
Macaca fascicularis
)
,
olive baboon (
Papio anubis
)
,
chimpanzee (
Pan troglodytes
)
, capuchin monkey
AntigenCD49f
Alternative names of antigenITGA6, CD49fB, VLA-6, VLA-6α
Molecular mass of antigen [kDa]124, 120(separately shown for human and mouse/rat)
Distribution of antigenstem cells, epithelial cells, lymphocytes, megakaryocytes, monocytes, platelets, T cells, cancer stem cells, hematopoietic stem and progenitor cells, ES and iPS cells, thymocytes, brain, kidney, liver, lung, ovary, spleen
Entrez Gene ID3655, 16403
RRIDAB_2751828, AB_2802026, AB_2802009, AB_2802050, AB_2802044, AB_2751859

References for CD49f Antibody, anti-human/mouse, REAfinity™

Publications

  1. Hynes, R. O. (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110(6): 673-687
  2. Aumailley, M. et al. (1990) Antibody to integrin α 6 subunit specifically inhibits cell-binding to laminin fragment 8. Exp. Cell Res. 188(1): 55-60
  3. Hemler, M. E. et al. (1988) Multiple very late antigen (VLA) heterodimers on platelets. Evidence for distinct VLA-2, VLA-5 (fibronectin receptor), and VLA-6 structures. J. Biol. Chem. 263: 7660-7665
  4. Carter, W. G. et al. (1990) Distinct functions for integrins α 3 β 1 in focal adhesions and α 6 β 4/bullous pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: relation to hemidesmosomes. J. Cell Biol. 111: 3141-3154

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