Clone:
GoH3
Type of antibody:
Primary antibodies
Isotype:
rat IgG2aκ
Applications:
FC, MICS, ICC
Alternative names:
ITGA6, α6 integrin, ITGA6B, VLA-6, CD49f, VLA-6α

Specifications for CD49f Antibody, anti-human/mouse

Overview

Clone GoH3 reacts with CD49f, a 120 kDa transmembrane glycoprotein also known as α6 integrin. Integrins are integral cell-surface proteins composed of an α chain and a β chain and are involved in cell adhesion as well as cell-surface mediated signaling. CD49f associates with integrin β1 chain (CD29) to form VLA-6 and with integrin β4 chain (CD104) to form the α6 β4 complex, which plays a critical structural role in the hemidesmosome and constitutes a receptor for laminin in epithelial cells. CD49f is furthermore expressed on T cells, monocytes, platelets, endothelial cells, trophoblasts of placenta, and spermatogonial stem cells. Clone GoH3 antibody has been reported to block laminin binding
in vitro
and to block integrin α6 function
in vivo
.

Alternative names

ITGA6, α6 integrin, ITGA6B, VLA-6, CD49f, VLA-6α

Detailed product information

Technical specifications

CloneGoH3
Clonalitymonoclonal
Isotyperat IgG2aκ
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies
Specieshuman, mouse, non-human primate, other
Cross-reactivityporcine, dog,
rhesus monkey (
Macaca mulatta
)
,
cynomolgus monkey (
Macaca fascicularis
)
,
olive baboon (
Papio anubis
)
,
chimpanzee (
Pan troglodytes
)
, capuchin monkey
AntigenCD49f
Alternative names of antigenITGA6, α6 integrin, ITGA6B, VLA-6, CD49f, VLA-6α
Molecular mass of antigen [kDa]124
Distribution of antigenepithelial cells, lymphocytes, megakaryocytes, monocytes, platelets, T cells, hematopoietic stem and progenitor cells, cancer stem cells, ES and iPS cells, thymocytes, brain, kidney, liver, lung, ovary, spleen
Entrez Gene ID3655
RRIDAB_2658552, AB_2658555, AB_2658556, AB_2658557

Reviews for CD49f Antibody, anti-human/mouse

CD49f FITC Antibody

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CD49f-FITC, human and mouse (130-097-245)

Antibody used in flow cytometry to detect mammary epithelial cells in lactating dairy cows. It worked perfectly and matched at 100% with bovine cells.

References for CD49f Antibody, anti-human/mouse

Publications

  1. Hynes, R. O. (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110(6): 673-687
  2. Aumailley, M. et al. (1990) Antibody to integrin α 6 subunit specifically inhibits cell-binding to laminin fragment 8. Exp. Cell Res. 188(1): 55-60
  3. Hemler, M. E. et al. (1988) Multiple very late antigen (VLA) heterodimers on platelets. Evidence for distinct VLA-2, VLA-5 (fibronectin receptor), and VLA-6 structures. J. Biol. Chem. 263: 7660-7665
  4. Carter, W. G. et al. (1990) Distinct functions for integrins α 3 β 1 in focal adhesions and α 6 β 4/bullous pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: relation to hemidesmosomes. J. Cell Biol. 111: 3141-3154
  5. Izadyar, F. et al. (2011) Identification and characterization of repopulating spermatogonial stem Hum. Reprod. 26: 1296-1306

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