Type of antibody:
Primary antibodies
rat IgG2aκ
Alternative names:
ITGA6, α6 integrin, ITGA6B, VLA-6, CD49f, VLA-6α

Specifications for CD49f Antibody, anti-human/mouse


Clone GoH3 reacts with CD49f, a 120 kDa transmembrane glycoprotein also known as α6 integrin. Integrins are integral cell-surface proteins composed of an α chain and a β chain and are involved in cell adhesion as well as cell-surface mediated signaling. CD49f associates with integrin β1 chain (CD29) to form VLA-6 and with integrin β4 chain (CD104) to form the α6 β4 complex, which plays a critical structural role in the hemidesmosome and constitutes a receptor for laminin in epithelial cells. CD49f is furthermore expressed on T cells, monocytes, platelets, endothelial cells, trophoblasts of placenta, and spermatogonial stem cells. Clone GoH3 antibody has been reported to block laminin binding
in vitro
and to block integrin α6 function
in vivo

Alternative names

ITGA6, α6 integrin, ITGA6B, VLA-6, CD49f, VLA-6α

Detailed product information

Technical specifications

Isotyperat IgG2aκ
Isotype controlIsotype Control Antibody, rat IgG2a
Type of antibodyPrimary antibodies
Specieshuman, mouse, non-human primate, other
Cross-reactivityporcine, dog,
rhesus monkey (
Macaca mulatta
cynomolgus monkey (
Macaca fascicularis
olive baboon (
Papio anubis
chimpanzee (
Pan troglodytes
, capuchin monkey
Alternative names of antigenITGA6, α6 integrin, ITGA6B, VLA-6, CD49f, VLA-6α
Molecular mass of antigen [kDa]124
Distribution of antigenepithelial cells, lymphocytes, megakaryocytes, monocytes, platelets, T cells, hematopoietic stem and progenitor cells, cancer stem cells, ES and iPS cells, thymocytes, brain, kidney, liver, lung, ovary, spleen
Entrez Gene ID3655
RRIDAB_2658552, AB_2658555, AB_2658556, AB_2658557

Resources for CD49f Antibody, anti-human/mouse


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Reviews for CD49f Antibody, anti-human/mouse

CD49f FITC Antibody

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CD49f-FITC, human and mouse (130-097-245)

Antibody used in flow cytometry to detect mammary epithelial cells in lactating dairy cows. It worked perfectly and matched at 100% with bovine cells.

References for CD49f Antibody, anti-human/mouse


  1. Hynes, R. O. (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110(6): 673-687
  2. Aumailley, M. et al. (1990) Antibody to integrin α 6 subunit specifically inhibits cell-binding to laminin fragment 8. Exp. Cell Res. 188(1): 55-60
  3. Hemler, M. E. et al. (1988) Multiple very late antigen (VLA) heterodimers on platelets. Evidence for distinct VLA-2, VLA-5 (fibronectin receptor), and VLA-6 structures. J. Biol. Chem. 263: 7660-7665
  4. Carter, W. G. et al. (1990) Distinct functions for integrins α 3 β 1 in focal adhesions and α 6 β 4/bullous pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: relation to hemidesmosomes. J. Cell Biol. 111: 3141-3154
  5. Izadyar, F. et al. (2011) Identification and characterization of repopulating spermatogonial stem Hum. Reprod. 26: 1296-1306

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CD49f Antibody, anti-human/mouse

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