Clone:
NKI-SAM1
Type of antibody:
Primary antibodies
Isotype:
mouse IgG2bκ
Applications:
FC, MICS, IF, IHC
Alternative names:
ITGA5, FNRA, VLA-5, VLA5A, VLA-5α

Specifications for CD49e Antibody, anti-human

Overview

The monoclonal antibody NKI-SAM1 reacts with human CD49e, also known as integrin α5 chain. Integrins are cell-surface receptors, expressed as heterodimers essential in various processes mediating intercellular or cellmatrix interaction. Integrin α5 is composed of a heavy and a light chain linked by a disulfide bond. CD49e associates non-covalently with the integrin ß1 (CD29) forming the very late activation antigen-5 (VLA5) complex which is expressed on many cell types including peripheral lymphocytes, monocytes, fibroblasts, and endothelial cells and is a receptor for fibronectin and fibrinogen but functions also as a receptor for laminin and several other extracellular matrix proteins.

Alternative names

ITGA5, FNRA, VLA-5, VLA5A, VLA-5α

Detailed product information

Technical specifications

CloneNKI-SAM1
Clonalitymonoclonal
Isotypemouse IgG2bκ
Isotype controlIsotype Control Antibody, mouse IgG2b
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman, non-human primate
Cross-reactivity
cynomolgus monkey (
Macaca fascicularis
)
AntigenCD49e
Alternative names of antigenITGA5, FNRA, VLA-5, VLA5A, VLA-5α
Molecular mass of antigen [kDa]110
Distribution of antigenB cells, dendritic cells, monocytes, NK cells, osteoblasts, platelets, T cells, stem cells, neutrophils, thymocytes
Entrez Gene ID3678
RRIDAB_2819595, AB_2658529, AB_2658530, AB_2819610

References for CD49e Antibody, anti-human

Publications

  1. Riedl, E. et al. (2000)
    Functional involvement of E-cadherin in TGF-beta 1-induced cell cluster formation of
    in vitro
    developing human Langerhans-type dendritic cells.
    J. Immunol. 165(3): 1381-1386
  2. Takada, Y. et al. (1987) The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis. Proc. Natl. Acad. Sci. U.S.A. 84: 3239-3243
  3. Takagi, J. et al. (2003) Structure of integrin alpha5beta1 in complex with fibronectin. EMBO J. 22: 4607-4615
  4. Lomakina, E. B and Waugh, R. E. (2009) Adhesion between human neutrophils and immobilized endothelial ligand vascular cell adhesion molecule 1: divalent ion effects Biophys. J. 96(1): 276-284

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