Clone:
R1-2
Type of antibody:
Primary antibodies
Isotype:
rat IgG2bκ
Applications:
FC, MICS, IF, IHC
Alternative names:
ITGA4, Itga4B, VLA-4α

Specifications for CD49d Antibody, anti-mouse

Overview

The monoclonal antibody R1-2 reacts with mouse CD49d, a 150 kDa Integrin family member, also known as integrin α4 chain. Integrins are cell-surface receptors, expressed as heterodimers essential in various processes mediating intercellular or cell-matrix interaction. CD49d associates non-covalently with the integrin ß or ß1 (CD29) forming the complex VLA4, which is expressed on peripheral lymphocytes, thymocytes, eosinophils, basophils, mast cells, dendritic cells, and monocytes. VLA4 plays a critical role in adhesion and migration of cells into tissues by binding to its ligand VCAM-1 (CD106). Together with the ß7 integrin, CD49d forms the heterodimer LPAM-1, which is a ligand for the mucosal vascular addressin (MAdCAM-1).

Alternative names

ITGA4, Itga4B, VLA-4α

Detailed product information

Technical specifications

CloneR1-2
Clonalitymonoclonal
Isotyperat IgG2bκ
Isotype controlIsotype Control Antibody, rat IgG2b
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD49d
Alternative names of antigenITGA4, Itga4B, VLA-4α
Molecular mass of antigen [kDa]111
Distribution of antigenB cells, dendritic cells, Langerhans cells, macrophages, mast cells, monocytes, NK cells, red blood cells, T cells, lymphocytes, basophils, eosinophils, cardiac muscle, placenta, skeletal muscle, smooth muscle
Entrez Gene ID16401
RRIDAB_2784236, AB_2660734, AB_2660735, AB_2660736, AB_2660737, AB_2660738, AB_2660739, AB_2660740, AB_2660741, AB_2660742, AB_2660743, AB_2660744, AB_2784237

References for CD49d Antibody, anti-mouse

Publications

  1. Fogler, W. E. et al. (1996) NK cell infiltration into lung, liver, and subcutaneous B16 melanoma is mediated by VCAM-1/VLA-4 interaction. J. Immunol. 156(12): 4707-4714
  2. Vermeulen, M. et al. (1998) Role of adhesion molecules in the homing and mobilization of murine hematopoietic stem and progenitor cells. Blood 92(3): 894-900
  3. Jia, G. Q. et al. (1999) Selective eosinophil transendothelial migration triggered by eotaxin via modulation of Mac-1/ICAM-1 and VLA-4/VCAM-1 interactions. Int. Immunol. 11(1): 1-10
  4. Berlin, C. et al. (1993) Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 74(1): 185-195
  5. Chacko, S. M. et al. (1989) Identification of a murine Peyer's patch-specific lymphocyte homing receptor as an integrin molecule with an alpha chain homologous to human VLA-4 alpha. Cell 56(1): 37-46

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CD49d Antibody, anti-mouse

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