Clone:
REA545
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC, ICC
Alternative names:
ITGA4, IA4

Specifications for CD49d Antibody, anti-human, REAfinity™

Overview

Clone REA545 recognizes the human CD49d antigen, which belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. CD49d, also known as the α4 integrin chain or VLA-4α chain, is a cell adhesion protein that is directly involved in mononuclear leukocyte trafficking. Dimerized with β7 integrin, the resulting α4β7 integrin binds VCAM-1 (CD106), MAdCAM-1, and fibronectin to facilitate the rolling of leukocytes along vascular epithelium. In T cells, on ligation of MAdCAM-1, α4β7 integrin also provides costimulation of T cell receptor/CD3–mediated signaling.
CD49d is expressed on most mononuclear leukocytes, both in circulation or in lymphoid or other tissues, as well as on eosinophils and basophils.
Additional information: Clone REA545 displays negligible binding to Fc receptors.

Alternative names

ITGA4, IA4

Detailed product information

Technical specifications

CloneREA545
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate, other
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
,
cynomolgus monkey (
Macaca fascicularis
)
, baboon,
chimpanzee (
Pan troglodytes
)
,
common marmoset (
Callithrix jacchus
)
,
squirrel monkey (
Saimiri sciureus
)
, horse, cattle (bovine, cow), sheep, dog, cat
AntigenCD49d
Alternative names of antigenITGA4, IA4
Molecular mass of antigen [kDa]111
Distribution of antigenT cells, leukocytes
Entrez Gene ID3676
RRIDAB_2733823, AB_2784239, AB_2784238, AB_2811390, AB_2811387, AB_2811444, AB_2811438, AB_2819760, AB_2819757, AB_2658511, AB_2658512, AB_2733822

References for CD49d Antibody, anti-human, REAfinity™

Publications

  1. Bulian, P. et al. (2014) CD49d is the strongest flow cytometry–based predictor of overall survival in chronic lymphocytic leukemia. J. Clin. Oncol. 32: 897-904
  2. Yoshino, N. et al. (2000)
    Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (
    Macaca fascicularis
    ) by using anti-human cross-reactive antibodies.
    Exp. Anim. 49(2): 97-110

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CD49d Antibody, anti-human, REAfinity™

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