Clone:
REAL478
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
Itga1, VLA-1, integrin α1

Specifications for CD49a Antibody, anti-human, REAdye_lease™

Overview

Clone REAL478 is an antibody fragment derived from the full CD49a antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL478 recognizes the cell adhesion molecule human CD49a, which is a 200 kDa heterodimeric integrin receptor. CD49a also known as integrin α1 interacts with integrin β1 (CD29) to form the VLA-1 complex which functions as a receptor for collagen and laminin-1. Integrin α1 plays a role in cell-cell adhesion and T cell proliferation and is expressed by activated T cells, NK cells, neuronal cells, fibroblasts and mesenchymal cells.
Most of the cancer tissues show a weak to moderate cytoplasmic expression of CD49a, whereas lymphomas, prostate and testicular cancers were mainly negative. Some pancreatic cancers showed strong positivity.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

Itga1, VLA-1, integrin α1

Detailed product information

Technical specifications

CloneREAL478
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCD49a
Alternative names of antigenItga1, VLA-1, integrin α1
Distribution of antigenfibroblasts, NK cells, T cells, neurons, mesenchymal stem cells

References for CD49a Antibody, anti-human, REAdye_lease™

Publications

  1. Hemler, M. E. et al. (1985) Biochemical characterization of VLA-1 and VLA-2. Cell surface heterodimers on activated T cells. J. Biol. Chem. 260: 15246-15252
  2. Miettinen, M. et al. (1993) Distribution of VLA integrins in solid tumors. Emergence of tumor-type-related expression. Patterns in carcinomas and sarcomas. Am. J. Pathol. 142(4): 1009-1018
  3. Boiret, N. et al. (2005) Characterization of nonexpanded mesenchymal progenitor cells from normal adult human bone marrow. Exp. Hematol. 33(2): 219-225
  4. Gharibi, A. (2017) ITGA1 is a pre-malignant biomarker that promotes therapy resistance and metastatic potential in pancreatic cancer. Sci Rep 7(1): 10060

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