Clone:
REA1238
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
BCM1, BLAST, Blast-1, Bcm-1, MEM-102, SLAMF2, Sgp-60

Specifications for CD48 Antibody, anti-mouse, REAfinity™

Overview

Clone REA1238 reacts with the CD48 mouse antigen, which is a 45 kDa GPI-linked glycoprotein also known as BCM1, blast-1 (human), or OX-45 (rat). CD48 belongs to the SLAM family including CD48, CD244, and CD150. These cell surface receptors were differentially expressed among functionally progenitors. Hematopoietic stem cells are highly purified as CD150
CD48
CD244
cells, multipotent hematopoietic progenitors are CD244
+
CD150
CD48
and most restricted progenitor cells are CD48
+
CD244
+
CD150
. In mouse, the ligands for CD48 are CD2 and CD244.
Additional information: Clone REA1238 displays negligible binding to Fc receptors.

Alternative names

BCM1, BLAST, Blast-1, Bcm-1, MEM-102, SLAMF2, Sgp-60

Detailed product information

Technical specifications

CloneREA1238
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD48
Alternative names of antigenBCM1, BLAST, Blast-1, Bcm-1, MEM-102, SLAMF2, Sgp-60
Molecular mass of antigen [kDa]22
Distribution of antigenstem cells, other
Entrez Gene ID12506
RRIDAB_2819679, AB_2819680, AB_2819681, AB_2819682, AB_2819683, AB_2819684, AB_2819685, AB_2819686, AB_2819678

References for CD48 Antibody, anti-mouse, REAfinity™

Publications

  1. Latchman, Y. et al. (1998) Cutting edge: Identification of the 2B4 molecule as a counter-receptor for CD48. J. Immunol. 161: 5809-5812
  2. Kato, K. et al. (1992) CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation. J. Exp. Med. 176: 1241
  3. Kiel, M.J. et al. (2005) SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121(7): 1109-1121

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