Clone:
REA1000
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CD45, LCA, L-CA

Specifications for CD45RC Antibody, anti-rat, REAfinity™

Overview

Clone REA1000 recognizes the RC isoform of the rat CD45 antigen, also known as leukocyte common antigen (LCA), which is a single-chain type I transmembrane glycoprotein. CD45 has multiple isoforms and differential glycosylation, CD45RC is the high molecular weight form of CD45. CD45 is expressed at high levels on all cells of hematopoietic origin except for erythrocyte and platelets. It plays a role in signal transduction through B and T cell antigen receptors. The CD45RC isoform is expressed on B cells, most cytotoxic T cells, and a subset of T helper cells, but not expressed on myeloid cells.
Additional information: Clone REA1000 displays negligible binding to Fc receptors.

Alternative names

CD45, LCA, L-CA

Detailed product information

Technical specifications

CloneREA1000
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesrat
AntigenCD45RC
Alternative names of antigenCD45, LCA, L-CA
Molecular mass of antigen [kDa]141
Distribution of antigenB cells, T cells, CD4+ T cells, CD8+ T cells
Entrez Gene ID24699
RRIDAB_2727752, AB_2727683, AB_2727753, AB_2727684, AB_2727754, AB_2727755, AB_2727685, AB_2727756, AB_2727757, AB_2727758, AB_2727686, AB_2727759, AB_2727751

References for CD45RC Antibody, anti-rat, REAfinity™

Publications

  1. Sunderland, C. A. et al. (1979) Purification with monoclonal antibody of a predominant leukocyte-common antigen and glycoprotein from rat thymocytes. Eur. J. Immunol. 9(2): 155-159
  2. Mojcik, D. L. et al. (1987) Monoclonal antibodies to RT7 and LCA antigens in the rat: cell distribution and segregation analysis. Hybridoma 6(5): 531-543

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