Clone:
REA747
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Alternative names:
Ptprc, GP180, L-CA, LY5, T200

Specifications for CD45 antibodies

Overview

REA747 recognizes the human CD45 antigen, a member of the protein tyrosine phosphatase (PTP) family, also known as the leukocyte common antigen (LCA). The CD45 molecule a type I transmembrane protein which is required for T and B cell activation and involved in cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 is expressed in different isoforms (CD45RA, CD45RB, CD45RC, CD45RAB, CD45RAC, CD45RBC, CD45RO, CD45R (ABC)) depending on the differentiation status of the cell. The CD45 antibody recognizes a common epitope of all CD45 isoforms. Additional information: Clone REA747 displays negligible binding to Fc receptors.

Applications

Reagent can be used for immunophenotyping by flow cytometry. Abnormal numbers of cells expressing this antigen or aberrant expression levels of the antigen can be expected in some disease states. It is important to understand the normal expression pattern for this antigen and its relationship to expression of other relevant antigens in order to perform appropriate analysis.
Expression of CD45 may be used as aid to diagnostic in the characterization of samples from individuals suspected with hematologic neoplasia.

Alternative names

Ptprc, GP180, L-CA, LY5, T200

Detailed product information

Technical specifications

CloneREA747
Isotyperecombinant human IgG1
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD45
Alternative names of antigenPtprc, GP180, L-CA, LY5, T200
Molecular mass of antigen [kDa]145
Distribution of antigenB cells, dendritic cells, lymphocytes, Langerhans cells, macrophages, leukocytes, monocytes, T cells, thymocytes, hematopoietic stem and progenitor cells

Resources for CD45 antibodies

Certificates

Please follow this
link
to download the Certificate of Conformity (CoC) by lot number.