Clone:
REA706
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CDw44, Epican, ECMR-III, PGP-I, CSPG9, EMCR III, HCELL, HUTCH-I, H-CAM

Specifications for CD44v6 Antibody, anti-human, REAfinity™

Overview

Clone REA706 recognizes the CD44v6 antigen. CD44 is the receptor for hyaluronic acid (HA), which plays an important role in cell migration, tumor growth, and progression. CD44 is involved in the modification of the activity of receptors including MET and the ERBB family of tyrosine kinases. CD44 is a marker for many types of cancer stem cells (CSC), including breast CSCs that possess higher tumorigenicity and metastatic potential, colorectal, pancreatic, and prostate CSCs. In addition, expression was observed in several cancers as well as on carcinoma cell lines. Here, CD44 plays a role in cancer cell migration and matrix adhesion in response to a cellular microenvironment, thus enhancing cellular aggregation and tumor cell growth. CD44 is also expressed on mesodermal cells, such as hematopoietic, fibroblastic, and glial cells.
Additional information: Clone REA706 displays negligible binding to Fc receptors.

Alternative names

CDw44, Epican, ECMR-III, PGP-I, CSPG9, EMCR III, HCELL, HUTCH-I, H-CAM

Detailed product information

Technical specifications

CloneREA706
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD44v6
Alternative names of antigenCDw44, Epican, ECMR-III, PGP-I, CSPG9, EMCR III, HCELL, HUTCH-I, H-CAM
Molecular mass of antigen [kDa]79
Distribution of antigenfibroblasts, hematopoietic stem and progenitor cells
Entrez Gene ID960
RRIDAB_2658208, AB_2658209, AB_2658210, AB_2658211, AB_2658212, AB_2658213, AB_2658214, AB_2658215, AB_2658207

References for CD44v6 Antibody, anti-human, REAfinity™

Publications

  1. Aruffo, A. et al. (1990) CD44 is the principal cell surface receptor for hyaluronate. Cell 61: 1303-1313
  2. Al-Hajj, M. et al. (2003) Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. U.S.A. 100: 3983-3988
  3. Collins, A. T. et al. (2005) Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res. 65: 10946-10951
  4. Patrawala, L. et al. (2006)
    Highly purified CD44
    +
    prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells.
    Oncogene 25: 1696-1708
  5. Dalerba, P. et al. (2007) Phenotypic characterization of human colorectal cancer stem cells. Proc. Natl. Acad. Sci. U.S.A. 104: 10158-10163
  6. Wang, L. et al. (2013) Enrichment of prostate cancer stem-like cells from human prostate cancer cell lines by culture in serum-free medium and chemoradiotherapy. Int. J. Biol. Sci. 9(5): 472-479

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