Clone:
REA503
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Spn, Lsn, Lsn1, gpL115, Ly-48

Specifications for CD43 Antibody, anti-rat, REAfinity™

Overview

Clone REA503 recognizes the rat CD43 cell surface antigen, also known as leukosialin or sialophorin, which is a 371 amino acid heavily glycosylated single-pass type 1 transmebrane glycoprotein.
CD43 is expressed by most hematopoietic cells including peripheral T cells, NK cells, granulocytes, monocytes, thymocytes, platelets, plasma cells, activated B cells, and hemotopoietic progenitor cells. Leukosialin is involved in the costimulation of cell activation and survival as well as in cell-cell adhesion and anti-adhesion, and plays a role in inducement the apoptosis of T cells and hematopoietic progenitor cells.
Additional information: Clone REA503 displays negligible binding to Fc receptors.

Alternative names

Spn, Lsn, Lsn1, gpL115, Ly-48

Detailed product information

Technical specifications

CloneREA503
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesrat
AntigenCD43
Alternative names of antigenSpn, Lsn, Lsn1, gpL115, Ly-48
Molecular mass of antigen [kDa]38
Distribution of antigenB cells, granulocytes, monocytes, NK cells, platelets, T cells, stem cells, hematopoietic stem and progenitor cells, plasma cells, thymocytes
Entrez Gene ID24796
RRIDAB_2658081, AB_2658082, AB_2658083, AB_2658084, AB_2658085, AB_2658086, AB_2658087, AB_2658088, AB_2658089, AB_2658090, AB_2658091, AB_2658092, AB_2658093, AB_2658080

References for CD43 Antibody, anti-rat, REAfinity™

Publications

  1. van den Berg, T. K. et al. (2001) Cutting Edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor Sialoadhesin (Siglec-1). J. Immunol. 166(6): 3637-3640
  2. Killeen, N. et al. (1987) The sequence of rat leukosialin (W3/13 antigen) reveals a molecule with O-linked glycosylation of one third of its extracellular amino acids. EMBO J. 6(13): 4029-4034
  3. Barclay. A. N. (1981) The localization of populations of lymphocytes defined by monoclonal antibodies in rat lymphoid tissues. Immunology 42(4): 593-600

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