Clone:
REA607
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
gpIIb/IIIa complex, integrin αIIbβ3

Specifications for CD41/CD61 Antibody, anti-human, REAfinity™

Overview

Clone REA607 recognizes the CD41/CD61 complex, also known as gpIIb/IIIa complex or integrin αIIbβ3. This cell adhesion molecule is a α/β transmembrane heterodimer of the ubiquitous integrin superfamily which is expressed by megakaryocytes and platelets. The CD41/CD61 complex plays an significant role in hemostasis and is also involved in fibrinogen binding and platelet aggregation.
Additional information: Clone REA607 displays negligible binding to Fc receptors.

Alternative names

gpIIb/IIIa complex, integrin αIIbβ3

Detailed product information

Technical specifications

CloneREA607
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD41/CD61
Alternative names of antigengpIIb/IIIa complex, integrin αIIbβ3
Distribution of antigenmegakaryocytes, platelets
Entrez Gene ID3674, 3690
RRIDAB_2751734, AB_2802027, AB_2802010, AB_2802037, AB_2802025, AB_2819707, AB_2819699, AB_2877032, AB_2877033, AB_2658032, AB_2658033, AB_2658036, AB_2658037, AB_2751794

References for CD41/CD61 Antibody, anti-human, REAfinity™

Publications

  1. Naik, U. P. et al. (1997) Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain. J. Biol. Chem. 272(8): 4651-4654
  2. Podolnikova, N. P. et al. (2014) The interaction of integrin αIIbβ3 with fibrin occurs through multiple binding sites in the αIIb β-propeller domain. J. Biol. Chem. 289(4): 2371-2383
  3. Corbel, C. et al. (2005) (alpha)IIb integrin, a novel marker for hemopoietic progenitor cells. Int. J. Dev. Biol. 49(2-3): 279-284

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CD41/CD61 Antibody, anti-human, REAfinity™

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