Clone:
MWReg30
Type of antibody:
Primary antibodies
Isotype:
rat IgG1κ
Applications:
FC, MICS, IF, IHC
Alternative names:
ITGA2B, GPIIb, CD41b, alphaIIb, GPalpha IIb

Specifications for CD41 Antibody, anti-mouse

Overview

Clone MWReg30 recognizes the mouse CD41 antigen, a single-pass type I membrane protein also known as integrin α2b or GPIIb. CD41 associates with CD61 to form the heterodimeric gpIIb/gpIIIa complex that is present on megakaryocytes, platelets, and early hematopoietic progenitors. The CD41/CD61 complex is a receptor for several adhesion molecules such as fibronectin, fibrinogen, plasminogen, and vitronectin and mediates platelets aggregation. CD41 expression marks the divergence of definitive hematopoietic precursors from the hemangioblasts or hemogenic endothelium during mouse embryonic development.

Alternative names

ITGA2B, GPIIb, CD41b, alphaIIb, GPalpha IIb

Detailed product information

Technical specifications

CloneMWReg30
Clonalitymonoclonal
Isotyperat IgG1κ
Isotype controlIsotype Control Antibody, rat IgG1
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD41
Alternative names of antigenITGA2B, GPIIb, CD41b, alphaIIb, GPalpha IIb
Molecular mass of antigen [kDa]109
Distribution of antigenmegakaryocytes, platelets
Entrez Gene ID16399
RRIDAB_2876914, AB_2658010, AB_2658011, AB_2658014, AB_2658015, AB_2658016, AB_2658017, AB_2658018, AB_2658019, AB_2658020, AB_2658021, AB_2658022, AB_2658023, AB_2752056

References for CD41 Antibody, anti-mouse

Publications

  1. Mikkola, H. K. et al. (2003) Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood 101(2): 508-516
  2. Thornton, M. A. et al. (1999) Characterization of the murine platelet alphaIIb gene and encoded cDNA. Blood 94(11): 3947-3950
  3. Chen, Y. Q. et al. (1992) Identification of the alpha IIb beta 3 integrin in murine tumor cells. J. Biol. Chem. 267(24): 17314-17320

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CD41 Antibody, anti-mouse

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