Clone:
REAL103
Type of antibody:
Releasable antibodies, Primary antibodies, Recombinant antibodies
Applications:
FC, MICS, IHC, IF
Alternative names:
CD4mut, L3T4, Leu-3, T4

Specifications for CD4 Antibody, anti-human,
REAlease
®

Overview

Clone REAL103 is an antibody fragment derived from the full CD4 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REAL103 recognizes the human CD4 antigen, a 55 kDa single-pass type I membrane protein also known as T4 or Leu-3. CD4 is highly expressed on T helper cells and at a lower level on monocytes and dendritic cells. It is involved in the recognition of MHC class II/peptide complexes by the TCR heterodimers and is the receptor for the human immunodeficiency virus (HIV).
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative names

CD4mut, L3T4, Leu-3, T4

Detailed product information

Technical specifications

CloneREAL103
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable antibodies, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCD4
Alternative names of antigenCD4mut, L3T4, Leu-3, T4
Distribution of antigenT cells, monocytes, dendritic cells
RRIDAB_2751065, AB_2751433, AB_2751415, AB_2751097, AB_2751078, AB_2751627, AB_2751585, AB_2751272, AB_2751266, AB_2784181, AB_2784180, AB_2784178, AB_2784179, AB_2784177, AB_2784182, AB_2784183, AB_2811714, AB_2751089

References for CD4 Antibody, anti-human,
REAlease
®

Publications

  1. Maddon, P. J. et al. (1985) The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family. Cell 42(1): 93-104
  2. Barclay, A. N. et al. (1993) CD4 and the immunoglobulin superfamily. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 342(1299): 7-12
  3. Tebas, P. et al. (2014) Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. N. Engl. J. Med. 370(10): 901-910

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CD4 Antibody, anti-human,
REAlease
®

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