Clone:
REAL785
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
Entpd1, ATPDase, NTPDase-1, SPG64, gp80

Specifications for CD39 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL785 is an antibody fragment derived from the full CD39 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL785 recognizes the 70 to 100 kDa membrane-bound human CD39 molecule, which is expressed on an effector/memory-like subset of FoxP3+ regulatory T cells. CD39 is an ectonucleotidase and catalyzes the hydrolysis of extracellular nucleotides, for example, ATP. In concert with CD73, an ecto-5’-nucleotidase, this can lead to the production of adenosine. High extracellular ATP concentrations indicate tissue injury and cell death and induce various pro-inflammatory responses in immune cells.
Through its enzymatic activity, CD39 can contribute to the suppressive function of regulatory T cells, for example, by eliminating extracellular ATP or by generating adenosine, which has suppressive effects on various immune cells.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

Entpd1, ATPDase, NTPDase-1, SPG64, gp80

Detailed product information

Technical specifications

CloneREAL785
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCD39
Alternative names of antigenEntpd1, ATPDase, NTPDase-1, SPG64, gp80
Distribution of antigenB cells, dendritic cells, T cells, regulatory T cells, tonsil, liver, colon, kidney, prostate
RRIDAB_2857734

References for CD39 Antibody, anti-human, REAdye_lease™

Publications

  1. Maliszewski, C. R. et al. (1994) The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization. J. Immunol. 153(8): 3574-3583
  2. Borsellino, G. et al. (2007)
    Expression of ectonucleotidase CD39 by FoxP3
    +
    reg cells: hydrolysis of extracellular ATP and immune suppression.
    Blood 110: 1225-1232