Clone:
REA941
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
DNGR-1, CLEC9A

Specifications for CD370 (CLEC9A) Antibody, anti-mouse, REAfinity™

Overview

Clone REA941 recognizes CD370 (CLEC9A) C-type lectin 9A, also known as DC NK lectin group receptor-1 (DNGR-1). It is a type II transmembrane glycoprotein of 264 amino acids expressed at high level on CD8a
+
dendritic cells and at lower level on mPDCA-1
+
plasmacytoid dendritic cells. CD370 (CLEC9A) recognizes necrotic cell associated epitopes and plays an important role in crosspresentation of dead cell derived antigens.
Additional information: Clone REA941 displays negligible binding to Fc receptors.

Alternative names

DNGR-1, CLEC9A

Detailed product information

Technical specifications

CloneREA941
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD370 (CLEC9A)
Alternative names of antigenDNGR-1, CLEC9A
Molecular mass of antigen [kDa]27
Distribution of antigendendritic cells, other, plasmacytoid dendritic cells
Entrez Gene ID232414
RRIDAB_2727963, AB_2727126, AB_2727071, AB_2727127, AB_2727072, AB_2727128, AB_2727073, AB_2727125, AB_2727070, AB_2728014

References for CD370 (CLEC9A) Antibody, anti-mouse, REAfinity™

Publications

  1. Sancho, D. et al. (2008) Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. J. Clin. Invest. 118(6): 2098-2110
  2. Sancho, D. et al. (2009) Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature 458(7240): 899-903
  3. Joffre, O. P. et al. (2010)
    Efficient and versatile manipulation of the peripheral CD4
    +
    T-cell compartment by antigen targeting to DNGR-1/CLEC9A.
    Eur. J. Immunol. 40(5): 1255-1265

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