Clone:
REA468
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
SDC2, HSPG, HSPG1, SYND2, Fibroglycan

Specifications for CD362 (Syndecan-2) Antibody, anti-human, REAfinity™

Overview

Clone REA468 recognizes the human CD362 antigen, a single-pass type I membrane protein which is also known as syndecan-2, fibroglycan, or heparan sulfate proteoglycan core protein (HSPG). The syndecans are a family of transmembrane receptors with roles in cell adhesion, migration, and growth factor signaling. CD362 is expressed on mesenchymal cells in the vasculature and, like the other members of its family, can be shed from the cell surface resulting in the release of its extracellular core protein. It is also expressed on neuronal and epithelial cells, and is the predominant syndecan expressed during embryonic development. Expression of CD362 is upregulated in several cancer cell lines. CD362 induces dendritic spine formation in hippocampal neurons, and this depends on phosphorylation of the CD362 cytoplasmic domain by the tyrosine kinase receptor EphB. In colon carcinoma cells CD362 expression affects adhesion, proliferation, and tumorigenic activity.
Additional information: Clone REA468 displays negligible binding to Fc receptors.

Alternative names

SDC2, HSPG, HSPG1, SYND2, Fibroglycan

Detailed product information

Technical specifications

CloneREA468
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD362 (Syndecan-2)
Alternative names of antigenSDC2, HSPG, HSPG1, SYND2, Fibroglycan
Molecular mass of antigen [kDa]20
Distribution of antigenneurons, epithelial cells, stem cells, mesenchymal stem cells
Entrez Gene ID6383
RRIDAB_2657753, AB_2657754, AB_2657755, AB_2657752

References for CD362 (Syndecan-2) Antibody, anti-human, REAfinity™

Publications

  1. De Rossi, G. et al. (2014) Shed syndecan-2 inhibits angiogenesis. J. Cell. Sci. 127(21): 4788-4799
  2. Whiteford, J. R. et al. (2011) Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148. Mol. Biol. Cell 22(19): 3609-3624
  3. Sundberg, M. et al. (2009) CD marker expression profiles of human embryonic stem cells and their neural derivatives, determined using flow-cytometric analysis, reveal a novel CD marker for exclusion of pluripotent stem cells. Stem Cell Res. 2(2): 113-124

Related products for
CD362 (Syndecan-2) Antibody, anti-human, REAfinity™

2 products available